罗振革博士加盟上海科技大学生命学院

罗振革副院长、正教授

所在学院	生命科学与技术学院
研究方向	神经发育与再生
联系方式	luozhg@@shanghaitech.edu.cn

个人简介

学习经历
1988年获得南开大学生物工程专业学士学位
1991获得军事医学科学院免疫学专业硕士学位
1995获得军事医学科学院免疫学专业博士学位

工作经历
1991.9-1992.8，解放军254医院传染科实验室工作
1995.8-1999.12，军事医学科学院先后担任助理研究员、副研究员
2000.1-2003.5，美国阿拉巴马大学伯明翰分校神经科学系从事博士后研究工作
2003.6-2018．8，中国科学院神经科学研究所先后任研究员、高级研究员、所长助理、副所长
2012-2018，担任上海科技大学特聘教授
2014-2018，担任中国科学院大学岗位教授
2018.9，加入上海科技大学担任生命科学与技术学院副院长、正教授(Tenured)

主要研究内容

总目标：阐明脑结构与神经环路形成的分子细胞机制；揭示神经生长与退化相关神经系统疾病机理；开发新的神经损伤修复手段。
主要研究内容：大脑皮层的发育与进化；神经生长与导向；突触形成与修剪；神经损伤与修复。

代表性论文

1. He, M., Ding, Y.T., Chu, C., Tang, J., Xiao, Q. and Luo, Z.G.* (2016) Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury. Proc. Natl. Acad. Sci. USA. 113(40):11324-11329.

2. Ju, X.C., Hou, Q.Q., Sheng, A.L., Wu, K.Y., Zhou, Y., Jin, Y., Wen, T.Q., Yang, Z.G., Wang, X.Q., Luo, Z.G.* (2016) The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. eLife. Aug 9;5. pii: e18197. doi: 10.7554/eLife.18197.

3. Wu, K.Y., Zuo, G. L., Li, X.F., Ye, Q., Deng, Y.Q., Huang, X. Y., Wu-Chun Cao, Qin, C. F., Luo, Z.G.* (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res. 26:645-654. (Cover story, Highlighted, and received the 2016 Sanofi-Cell Research Outstanding Paper Award).

4. Wu, K.Y., He, M., Hou, Q.Q., Sheng, A.L., Yuan, L., Liu, Y., Liu, W.W., Li, G., Jiang, X.Y., Luo, Z.G.* (2014) Semaphorin-3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and callosal axon projection. Sci. Signal. 7, ra81.

5. Xu, X.H., Deng, C.Y., Liu Y., He, M., Peng, J., Wang, T., Yuan, L., Zheng, Z.S., Blackshear, P.J & Luo, Z.G.* (2014) MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell Res. 24: 576–594.

6. Wang, J.Y., Chen, F., Fu, X.Q., Ding, C.S., Zhou, L., Zhang, X.H. & Luo, Z.G.* (2014) Caspase-3 cleavage of disheveled induces elimination of postsynaptic structures. Dev. Cell 28:670–684 (Highlighted by Preview in Developmental Cell 28, 604-606).

7. Deng, C.Y., Lei, W.L., Xu, X.H., Ju, X.C., Liu, Y. & Luo, Z.G.* (2014) Jip1 mediates anterograde transport of Rab10 cargos during neuronal polarization. J. Neurosci. 34:1710-1723.

8. Liu, Y., Xu, X.H., Chen, Q., Wang, T., Deng, C.Y., Song, B.L., Du, J.L., Luo, Z.G.* (2013) Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat. Commun. 4:2005 doi: 10.1038/ncomms3005.

9. Lei, W.L., Xing, S.G., Deng, C.Y., Ju, X.C., Jiang, X.Y., Luo, Z.G.* (2012) Laminin/beta1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization. Cell Res. 22:954-972.

10. Wang, T., Liu, Y., Xu, X.H., Deng, C.Y., Wu, K.Y., Zhu, J., Fu, X.Q., He,M., and Luo, Z.G.* (2011) Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization. Dev. Cell. 21:431-444. (Cover story and highlighted by “Faculty of 1000 Biology”).

11. Yang, G.Y., Liang, B., Zhu, J., and Luo, Z.G.*(2011) Calpain activation by wingless-type MMTV integration site family, member 5A (Wnt5a) promotes axonal growth. J. Biol. Chem. 286: 6566-6576. (Highlighted by “Faculty of 1000 Biology”).

12. Wang, J., Fu, X.Q., Lei, W.L., Wang, T., Sheng, A.L., Luo, Z.G.* (2010) Nuclear Factor Kappa B Controls AChR Clustering by Regulating Rapsyn Expression at the Neuromuscular Junction. J. Neurosci. 30: 11104-11113.

13. Liang, B., Duan, B.Y., Zhou, X.P., Gong, J.X., Luo, Z.G.* (2010) Calpain activation promotes bace1 expression, APP processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Biol Chem. 285: 27737-27744.

14. Zhou, X.P., Wu, K.Y., Liang, B., Fu, X.Q., Luo, Z.G.*(2008) TrkB-mediated Activation of Geranylgeranyltransferase I Promotes Dendritic Morphogenesis. Proc. Natl. Acad. Sci. USA. 105: 17181-17186.

15. Wang, J., Ruan, N.J., Qian, L., Chen, F., Luo, Z.G.*(2008) Wnt/β-catenin signaling suppresses rapsyn expression and inhibits AChR clustering at the neuromuscular junction. J. Biol. Chem. 283: 21668-21675.

16. Zhang, X., Zhu, J., Yang, G.Y., Wang, Q.J., Qian, L., Chen, Y.M., Chen, F., Tao, Y., Hu, H.S., Wang, T., and Luo, Z.G.*(2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol. 9, 743-754. (Highlighted by News and Views in the same issue of Nat. Cell Biol., “Faculty of 1000 Biology”, and Nature China).

17. Chen, F., Qian, L., Yang, Z.H., Huang, Y., Ngo, S.T., Ruan, N.J., Wang, J., Schneider, C., Noakes, P.G., Ding, Y.Q., Mei, L., and Luo, Z.G.* (2007) Rapsyn interaction with Calpain stabilizes AChR clusters at the neuromuscular junction. Neuron 55: 247-260. (Highlighted by “Faculty of 1000 Biology”).

18. Chen, Y.M., Wang, Q.J., Hu, H.S.,Yu, P.C., Zhu, J., Drewes, G., Piwnica-Worms, H., Luo, Z.G.* (2006) Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/aPKC complex in regulating hippocampal neuronal polarity. Proc. Natl. Acad. Sci. USA 103: 8534-8539.