上海科技大学人力资源管理
ShanghaiTech University Human Resources
Quanjiang Ji    Assistant Professor、PI
Institute School of Physical Science and Technology
Research Area Chemical Biology and Synthetic Biology
Contact Info. quanjiangji@@shanghaitech.edu.cn
 
  Biography  
2016-now, assistant professor、PI (tenure-track),School of Physical Science and Technology, ShanghaiTech University;2014-2016, postdoc, College of Chemistry, University of California, Berkeley;2009-2014, Ph.D., Department of Chemistry, The University of Chicago; 2005-2009, B.S., Department of Chemistry, Nanjing University.
  Research Interests  
Our lab is interested in developing CRISPR-Cas9-based biotechnology for applications in synthetic biology, in particular in biofuel production and bioremediation. We are also interested in uncovering unexplored virulence regulatory and antibiotics resistant mechanisms of major human pathogens as well as drug development to counter infections.
  Selected Publications  


Independent Publications:

 3. Song, L., Zhang, Y., Chen, W., Gu, T., Zhang, S.Y., Ji, Q.* (2018) Mechanistic insights into staphylopine-mediated metal acquisition.  Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.1718382115.

  

2. Gu, T.#, Zhao, S.#, Pi, Y., Chen, W., Chen, C., Liu, Q., Li, M., Han, D.*, Ji, Q.* (2018) Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase. Chem Sci. 9, 3248-53.

  

 

1. Chen, W., Zhang, Y., Yeo, W.S., Bae, T., Ji, Q.* (2017) Rapid and efficient genome editing in Staphylococcus aureus by using an engineered CRISPR/Cas9 system. J Am Chem Soc 139: 3790-5.

  

Selected Ph.D. & Postdoc. Publications:


7. Fu, Y., Luo, G.Z., Chen, K., Deng, X., Yu, M., Han, D., Hao, Z., Liu, J., Lu, X., Doré, L.C., Weng, X., Ji, Q., Mets, L., He, C. (2015) N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas. Cell. 161, 879-92.


6. Shan, C.#, Elf, S.#, Ji, Q., Kang, H.B., Zhou, L., Hitosugi, T., Jin, L., Lin, R., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.L., Sudderth, J., Jiang, L., DeBerardinis, R.J., Wu, S., Li, Y., Mao, H., Chen, P.R., Wang, D., Chen, G.Z., Lonial, S., Arellano, M.L., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J.*, Chen, J.* (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 55, 552-65.


5. 
Ji, Q.#, Zhao, B.S.#, He, C.* (2013) A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells. Chem Commun. 49, 8027-9.


4. Ji, Q., Zhang, L., Jones, M.B., Sun, F., Deng, X., Liang, H., Cho, H., Brugarolas, P., Gao, Y.N., Peterson, S.N., Lan, L., Bae, T., He, C.* (2013) Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 110, 5010-5.


3. Sun, F., Ding, Y., Ji, Q., Liang, Z., Deng, X., Wong, C.C., Yi, C., Zhang, L., Xie, S., Alvarez, S., Hicks, L.M., Luo, C., Jiang, H., Lan, L.*, He, C.* (2012) Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance. Proc Natl Acad Sci U S A. 109, 15461-6.


2. Ji, Q.
#, Zhang, L.#, Sun, F., Deng, X., Liang, H., Bae, T., He, C.* (2012) Staphylococcus aureus CymR is a new thiol-based oxidation-sensing regulator of stress resistance and oxidative response. J Biol Chem. 287, 21102-9.


1. Sun, F.
#Ji Q.#, Jones, M.B., Deng, X., Liang, H., Frank, B., Telser, J., Peterson, S.N., Bae, T.*, He, C.* (2012) AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureusJ Am Chem Soc. 134, 305-14.


(# co-first author; * corresponding author)