上海科技大学人力资源管理
ShanghaiTech University Human Resources

Katsuhiko Mikoshiba        正教授

所在学院

免疫化学研究所

研究方向

Cell calcium signaling

联系方式

mikosiba@shanghaitech.edu.cn

  

Macintosh HD:Users:mikoshiba:Library:Containers:com.apple.mail:Data:Library:Mail Downloads:A1017064-C485-498E-92A4-6C0EA0D9C763:PastedGraphic-2.pdf

  

  

个人简介

  

  

学习经历

1969          M.D. Keio University School of Medicine

1973          Ph.D. Keio University

工作经历

1973-1974      Assistant Professor, Dept. of Physiology,   Keio Univ. School of Medicine

1974-1982      Lecturer, Dept. of Physiology, Keio Univ.   School of Medicine

1976-1977      Research Associate Pasteur Institute,   Paris, France (c/o Prof. Jean-Pierre Changeux)

1982-1985      Associate Prof., Department of   Physiology, Keio Univ. School of Medicine

1985-1992      Professor, Institute for Protein   Research, Osaka University

1986-1991      Professor, National Institute for Basic   Biology, Okazaki (Adjunct position)

1992-1997      Chief Scientist, Molecular Neurobiology   Laboratory, RIKEN, Tsukuba (Adjunct position)

1992-2007      Professor, The Institute of Medical   Science, The University of Tokyo

1998-2009      Team Leader, Group Director, RIKEN Brain   Science Institute (BSI) (Adjunct position)

2003-2015      Foreign Professor (Adjunct Professor) at   Karolinska Institute (received an honorary doctorate from Karolinska   Institute)

2005-present Member of Science Council of Japan

2007-present Professor Emeritus of University of Tokyo

2008-2011      Foreign Professor of Seoul National   University (Korea) (World Class University Professor, WCU Prof. program)

2009-2019      Senior Team Leader, Lab. for   Developmental Neurobiol., BSI, RIKEN

2019-present  Professor, SIAIS (Shanghai Institute for   Advanced Immunochemical Studies), ShanghaiTech University

  

  

主要研究内容

  

  

Role of calcium   signaling in cell function and diseases.

  

  

代表性论文

  

  

1.  Furuichi T, et al. Primary   structure and functional expression of the inositol   1,4,5-trisphosphate-binding protein P400. Nature 342(6245):32-8.   (1989)

2.  Miyazaki S et al. Block of Ca2+   wave and Ca2+ oscillation by antibody to the inositol   1,4,5-trisphosphate receptor in fertilized hamster eggs.  Science 257:251-5.   (1992)

3.  Matsumoto M et al.Ataxia and   epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate   receptor. Nature 379(6561):168-71. (1996)

4.  Kume S et al., Role of   inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus   embryos. Science 278(5345):1940-3. (1997)

5.  Takei K et al. Regulation of   nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth   cones. Science 282:1705-1708. (1998)

6.  Nagai, T et al. A variant of   yellow fluorescent protein with fast and efficient maturation for   cell-biological applications.  Nature. Biotechnol. 20   87-90 (2002)

7.  Saneyoshi T et al.  The   Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus   embryos.  Nature 417:295-299. (2002)

8.  Higo T et al.   Subtype-specific and ER lumenal environment-dependent regulation of inositol   1,4,5-trisphosphate receptor type 1 by ERp44.   Cell 120(1):85-98.   (2005)

9.  Futatsugi A et al. IP3   receptor types 2 and 3 mediate exocrine secretion underlying energy   metabolism.   Science 309(5744):2232-4. (2005)

10.  Ando H et al. IRBIT   suppresses IP3 receptor activity by competing with IP3 for the common binding   site on the IP3 receptor.   Molecular Cell 22(6):795-806.   (2006)

11.  Higo T et al. Mechanism   of ER stress-induced brain damage by IP3 receptor. Neuron 68(5):865-78.   (2010)

12.  Horikawa K et al.   Spontaneous network activity visualized by ultrasensitive Ca2+indicators,   yellow Cameleon-Nano. Nature Methods 7:729-732. (2010)

13.  Klar J et al. InsP3R2 mutations   cause anhidrosis in humans and hypohidrosis in mice.   J.   Clinical Investigation 124(11): 4773-80 (2014)

  

14.Tsuboi D et al. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA   for synaptic plasticity. Nature Neurosci. 18(5):   698-707. (2015)

  

15. Hisatsune C   et al. ERp44 Exerts redox-dependent control of blood pressure at the ER.Molecular Cell. 58(6): 1015-27. (2015)


16. Monai H et al.   Calcium imaging reveals glial involvement in transcranial direct current   stimulation-induced plasticity in mouse brain. Nature Commun doi: 10.1038/ncomms11100 (2016)

  

17.Bonneau B et al.   IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and   by promoting ER-mitochondria contact. eLife DOI10.7554/eLife19896 (2016)

18.   Hamada K, et al. IP3-mediated   gating mechanism of the IP3 receptor revealed by mutagenesis and   X-ray crystallography.Proc Natl Acad Sci 114(18): 4661-4666. (2017)