上海科技大学人力资源管理
ShanghaiTech University Human Resources

郑宜君     助理教授,研究员

所在学院

物质科学与技术学院

研究方向

(1) User-programmable biomaterials for dynamic cell culture platformsand (2) Molecular tools for cellular mechanosensing

联系方式

zhengyj@@shanghaitech.edu.cn

 


 

个人简介

 


11/2019~now, Assistant Professor at Shanghai Technology University, China 
10/2015~10/2019, Postdoc at INM-Leibniz Institute for New Materials, Germany 
8/2011~9/2013, Postdoc at MPI for Polymer Research, Germany 
Ph.D. at Peking University (Sept. 2006-Jul. 2011), China 
Visiting student at University of South Carolina (Jan. 2010-Jun. 2010), USA 
Bachelor at Beijing Normal University (Sept. 2002-Jul. 2006), China


 

研究内容

 


Our research focus on developing advanced dynamic biomaterials mimicking extracellular matrix to understand how cells interact with their environment and to gain insight into the manipulating mechanism of cell functions. In the current stage, we are particularly interested no two topics: (1) User-programmable biomaterials for dynamic cell culture platformsand (2) Molecular tools for cellular mechanosensing.

(1) User-programmable biomaterials for dynamic cell culture platforms

We develop new classes of user-programmable hydrogels with special emphasis on the use of multiple photochemical reactions that govern 4D material responsiveness, physicochemical tunability, and biophysical alterations, in an orthogonal manner.


(2) Molecular tools for cellular mechanosensing.

One of the central challenges in cellular mechanotransduction is the understanding of the molecular mechanisms that enable cells to modulate their mechanical responses and to sense and actively direct the biophysical properties of the ECM. To elucidate these fundamental mechanisms, cellular mechanotransduction should be studied at molecular levels. We develop molecular tools that can apply or detect forces at individual receptors within readily formed cell-ECM or cell-cell contacts.



 

代表性论文

 


  1. Y. Zheng*, M. Han, Q. Jiang, J. Feng, Bin. Li, A. del Campo, “4D hydrogels for dynamic cell culture with orthogonal, wavelength-regulated stiffening and cell adhesiveness”, Materials Horizons 201920 DOI: 10.1039/C9MH00665F.

  2. Y. Zheng, A. Farrukh, A. del Campo “Optoregulated Biointerfaces to Trigger Cellular Responses”, Langmuir, 2018, Online, DOI:10.1021/acs.langmuir.1028b02634

  3. Y. Zheng*, D. Wang, J. Cui, M. Mezger, G. K. Auernhammer, K. Koynov, H.-J. Butt, T. Ikeda, “Redox-Responsive and Thermoresponsive Supramolecular Nanosheet Gels with High Young's Moduli”, Macromol. Rapid Commun. 2018,39, DOI:10.1002/marc.201800282.

  4. Y. Zheng, X. Liu, J. Xu, H. Zhao, X. Hou, J. Cui “Thermo-responsive mobile interfaces with switchable wettability, optical properties, and penetrability”, ACS Appl. Mat. Interfaces2017, 9, 35483-35491.

  5. Z.-S. Wu, Y. Zheng, S. Zheng, S. Wang, C. Sun, K. Parvez, T. Ikeda, X. Bao, K. Muellen, X. Feng, “Stacked-Layer Heterostructure Films of 2D Thiophene Nanosheets and Graphene for High-Rate All-Solid-State Pseudocapacitors with Enhanced Volumetric Capacitance.” Adv. Mater., 2017, 29, DOI:10.1002/adma.201770020

  6. Y. Zheng, J. Cui, T. Ikeda “Click functionalization of phenyl-capped bithiophene on azide-terminated self-assembled monolayers”, Applied Surface Science, 2015, 355, 213-217.

  7. Y. Zheng, H. Zhou, D. Liu, F. George, W. Manfred; K. Kaloian, M. Mezger, H.-J. Butt, T. Ikeda, “Thiophene Supramolecular Nanosheet”, Angew. Chem. Int. Ed., 2013, 52, 4845-4848.

  8. Y. Zheng, D. Liu, H.-J. Butt, T. Ikeda, “Synthesis and Properties of Phenyl-capped Cyclohexyl[c]-oligothiophenes”, Synth. Met., 2013, 181, 1-9.

  9. Y. Zheng, J. Cui, J. Zheng, X. Wan, “Near-infrared Electrochromic and Chiroptical Switching Polymers: Synthesis and Characterization of Helical Poly(N-propargylamides) Carrying Anthraquinone Imide Moieties in Side Chains”, J. Mater. Chem., 2010, 20, 5915-5922.

  10. Y. Zheng, K. Yao, J. Lee, D. Chandler, J. Wang, C. Wang, F. Chu, C. Tang, “Well-Defined Renewable Polymers Derived from Gum Rosin”, Macromolecules, 2010, 43, 5922-5924.

  11. Y. Zheng, J. Zheng, L. Dou, W. Qiao, X. Wan, “Synthesis and Characterization of a Novel kind of Near-infrared Electrochromic Polymers Containing an Anthraquinone Imide Group and Ionic Moieties”, J. Mater. Chem., 2009, 19, 8470-8477.