上海科技大学人力资源管理
ShanghaiTech University Human Resources

王权     助理教授、研究员

所在学院

生命科学与技术学院/免疫化学研究所

研究方向

微生物生物能量代谢系统组成与结构;真核细胞线粒体与天然免疫;冷冻电子显微学。

联系方式

wangq@@shanghaitech.edu.cn

 

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个人简介

 

 

2009年本科毕业于南开大学信息技术与科学学院;2014年博士毕业于南开大学生命科学学院;2014年至2018年在中国科学院生物物理研究所任助理研究员;2014年至2015年在牛津大学牛津粒子成像中心访问;2018年至2019年在中国科学院生物物理研究所任副研究员;2019年至2020年在中国科学院生物物理研究所任研究员、课题组长;20202月加入上海科技大学生命科学与技术学院/免疫化学研究所任助理教授、研究员。

 

 

主要研究内容

 

 

致力于利用冷冻电子显微等成像技术,在多尺度下研究结核分枝杆菌、幽门螺旋杆菌等病原微生物能量代谢系统的分子组成、结构特征与功能机制,以及真核细胞能量工厂”-线粒体在调节宿主天然免疫应对病原菌感染过程中的作用。同时,亦通过干预生物能量代谢系统,开展抗耐药菌和抗肿瘤的药物筛选与研发工作。相关成果在SciencePNAS等国际期刊发表。

 

 

代表性论文

 

 

Structural Biology

1.    Hongri Gong#; Jun Li#; Ao Xu#; Yanting   Tang; Wenxin Ji; Ruogu Gao; Shuhui Wang; Lu Yu; Changlin Tian; Jingwen Li;   Hsin Yung Yen; Sin Man Lam; Guanghou Shui; Xiuna Yang; Yuna Sun; Xuemei Li;   Minze Jia; Cheng Yang; Biao Jiang; Zhiyong Lou; Carol V Robinson; Luet Lok   Wong; Luke W Guddat; Fei Sun*; Quan Wang*; Zihe Rao*, An electron   transfer path connects subunits of a mycobacterial respiratory supercomplex ,   Science, 2018.10.25, 362(6418): 0~eaat8923 [Representative Publication,   Co-corresponding Author]

2.    Wenxia Liu#; Aijun   Liu; Hailong Gao; Quan Wang; Limin Wang; Eberhard Warkentin; Zihe Rao;   Hartmut Michel*; Guohong Peng*, Structural properties of the peroxiredoxin   AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus, Biochimica et   Biophysica Acta-General Subjects, 2018.12, 1862(12): 2797~2805

3.    Kotecha Abhay#; Wang   Quan; Dong Xianchi; Ilca Serban L; Ondiviela Marina; Zihe Rao; Seago   Julian; Charleston Bryan; Fry Elizabeth E; Abrescia Nicola G A; Springer   Timothy A*; Huiskonen Juha T*; Stuart David I*, Rules of engagement between alpha   v beta 6 integrin and foot-and-mouth disease virus, Nature Communications,   2017.05.23, 8: 0~15408

4.    Dang, Minghao#; Wang,   Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li,   Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe*, Molecular   mechanism of SCARB2-mediated attachment and uncoating of EV71., Protein &   Cell, 2014.9, 5(9): 692~703

5.    Li, Baobin#; Wang,   Quan#;   Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei;   Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong*, Bunyamwera virus possesses a   distinct nucleocapsid protein to facilitate genome encapsidation.,   Proceedings of the National Academy of Sciences of the United States of   America, 2013.05.28, 110(22): 9048~9053 [Representative Publication,   Co-first Author]

6.    Chen, Qingfeng#; Chen,   Xiangsong#;   Wang, Quan; Zhang, Faben; Lou, Zhiyong*; Zhang, Qifa*; Zhou, Dao-Xiu*,   Structural basis of a histone H3 lysine 4 demethylase required for stem   elongation in rice., PLoS Genetics, 2013, 9(1)

7.    Chen, Qingfeng#; Wang,   Quan; Xiong, Lizhong*; Lou, Zhiyong*, A structural view of the conserved   domain of rice stress-responsive NAC1., Protein Cell, 2011.1, 2(1): 55~63

8.    Wang, Hui#; Morita,   Masahiro; Yang, Xiuna; Suzuki, Toru; Yang, Wen; Wang, Jiao; Ito, Kentaro; Wang,   Quan; Zhao, Cong; Bartlam, Mark*; Yamamoto, Tadashi*; Rao, Zihe, Crystal   structure of the human CNOT6L nuclease domain reveals strict poly(A)   substrate specificity., The EMBO Journal, 2010.8.4, 29 (15): 2566~2576

Drug Discovery

9.    Dong, Jing#; Zhang, Yong;   Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Yang, Cheng; Wang, Quan; Li,   Xuemei*; Deng, Xuming*, Baicalin inhibits the lethality of Shiga-like toxin 2   in mice., Antimicrobial Agents and Chemotherapy, 2015.11, 59(11): 7054~7060

10.Cao, Shujuan#; Yu, Liang;   Mao, Jingyuan; Wang, Quan; Ruan, Jishou*, Uncovering the Molecular   Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network.,   PLos One, 2015, 10(12)

11.Shanshan Qin#; Yiran   Ren#; Xu Fu; Jie Shen; Xin Chen; Quan Wang; Xin Bi; Wenjing Liu; Lixin   Li; Guangxin Liang; Cheng Yang; Wenqing Shui*, Multiple ligand detection and   affinity measurement by ultrafiltration and mass spectrometry analysis   applied to fragment mixture screening, Analytica Chimica Acta, 2015.7.30,   886: 98~106

12.Chen, Xin#; Qin,   Shanshan; Chen, Shuai; Li, Jinlong; Li, Lixin; Wang, Zhongling; Wang,   Quan; Lin, Jianping; Yang, Cheng; Shui, Wenqing*, A ligand-observed mass   spectrometry approach integrated into the fragment-based lead discovery   pipeline., Scientific Reports, 2015, 5: 8361~8361

13.Dong, Jing#; Zhang, Yong;   Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Li, Rui; Yang, Cheng; Wang, Quan;   Li, Xuemei; Deng, Xuming*, Baicalin inhibits the lethality of ricin in mice   by inducing protein oligomerization., Journal of Biological Chemistry,   2015.5.15, 290(20): 12899~12907

14.Dazhi Liu#;   Zhen Tian; Zhihui Yan; Lixin Wu; Yan Ma; Quan Wang; Wei Liu*; Honggang   Zhou; Cheng Yang, Design, synthesis and evaluation of   1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors,   Bioorganic & Medicinal Chemistry, 2013.6.1, 21(11): 2960~2967