上海科技大学人力资源管理
ShanghaiTech University Human Resources
Zhen-Ge Luo    Vice Dean, Professor
Institute School of Life Science and Technology
Research Area Neural Development and Regeneration
Contact Info. luozhg@@shanghaitech.edu.cn
 
  Biography  
Dr. Luo received his BS degree from Nankai University, Tianjin in 1988 and his Ph. D. degree from Academy of Military Medical Sciences (AMMS), Beijing in 1995. He was appointed as associate investigator at AMMS in 1998 and received post-doctoral training in the department of neurobiology, University of Alabama at Birmingham (UAB), USA from January 2000 to May 2003. He worked in the Institute of Neuroscience (ION), Chinese Academy of Sciences (CAS), as a Principal Investigator from 2003-2018. He joined the School of Life Science and Technology (SLST) at ShanghaiTech University as a tenured Full Professor since September 2018.
  Research Interests  
We aim to decipher molecular and cellular mechanisms underlying neural development and brain wiring. We are also interested in developing novel strategies to promote neuronal regeneration after injury. Major topics include: cortex development and evolution; nerve growth and guidance; synapse formation and pruning; neuronal injury and repair.
  Selected Publications  

1. He, M., Ding, Y.T., Chu, C., Tang, J., Xiao, Q. and Luo, Z.G.* (2016) Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury. Proc. Natl. Acad. Sci. USA. 113(40):11324-11329.

2. Ju, X.C., Hou, Q.Q., Sheng, A.L., Wu, K.Y., Zhou, Y., Jin, Y., Wen, T.Q., Yang, Z.G., Wang, X.Q., Luo, Z.G.* (2016) The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. eLife. Aug 9;5. pii: e18197. doi: 10.7554/eLife.18197.

3. Wu, K.Y., Zuo, G. L., Li, X.F., Ye, Q., Deng, Y.Q., Huang, X. Y., Wu-Chun Cao, Qin, C. F., Luo, Z.G.* (2016) Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice. Cell Res. 26:645-654. (Cover story, Highlighted, and received the 2016 Sanofi-Cell Research Outstanding Paper Award).

4. Wu, K.Y., He, M., Hou, Q.Q., Sheng, A.L., Yuan, L., Liu, Y., Liu, W.W., Li, G., Jiang, X.Y., Luo, Z.G.* (2014) Semaphorin-3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and callosal axon projection. Sci. Signal. 7, ra81.

5. Xu, X.H., Deng, C.Y., Liu Y., He, M., Peng, J., Wang, T., Yuan, L., Zheng, Z.S., Blackshear, P.J & Luo, Z.G.* (2014) MARCKS regulates membrane targeting of Rab10 vesicles to promote axon development. Cell Res. 24: 576–594.

6. Wang, J.Y., Chen, F., Fu, X.Q., Ding, C.S., Zhou, L., Zhang, X.H. & Luo, Z.G.* (2014) Caspase-3 cleavage of disheveled induces elimination of postsynaptic structures. Dev. Cell  28:670–684 (Highlighted by Preview in Developmental Cell 28, 604-606).

7. Deng, C.Y., Lei, W.L., Xu, X.H., Ju, X.C., Liu, Y. & Luo, Z.G.* (2014) Jip1 mediates anterograde transport of Rab10 cargos during neuronal polarization. J. Neurosci. 34:1710-1723.

8. Liu, Y., Xu, X.H., Chen, Q., Wang, T., Deng, C.Y., Song, B.L., Du, J.L., Luo, Z.G.* (2013) Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Nat. Commun. 4:2005 doi: 10.1038/ncomms3005.

9. Lei, W.L., Xing, S.G., Deng, C.Y., Ju, X.C., Jiang, X.Y., Luo, Z.G.* (2012) Laminin/beta1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization. Cell Res. 22:954-972.

10. Wang, T., Liu, Y., Xu, X.H., Deng, C.Y., Wu, K.Y., Zhu, J., Fu, X.Q., He,M., and Luo, Z.G.* (2011) Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization. Dev. Cell. 21:431-444. (Cover story and highlighted by “Faculty of 1000 Biology”).

11. Yang, G.Y., Liang, B., Zhu, J., and Luo, Z.G.*(2011) Calpain activation by wingless-type MMTV integration site family, member 5A (Wnt5a) promotes axonal growth. J. Biol. Chem. 286: 6566-6576. (Highlighted by “Faculty of 1000 Biology”).

12. Wang, J., Fu, X.Q., Lei, W.L., Wang, T., Sheng, A.L., Luo, Z.G.* (2010) Nuclear Factor Kappa B Controls AChR Clustering by Regulating Rapsyn Expression at the Neuromuscular Junction. J. Neurosci. 30: 11104-11113.

13. Liang, B., Duan, B.Y., Zhou, X.P., Gong, J.X., Luo, Z.G.* (2010) Calpain activation promotes bace1 expression, APP processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Biol Chem. 285: 27737-27744.

14. Zhou, X.P., Wu, K.Y., Liang, B., Fu, X.Q., Luo, Z.G.*(2008) TrkB-mediated Activation of Geranylgeranyltransferase I Promotes Dendritic Morphogenesis. Proc. Natl. Acad. Sci. USA. 105: 17181-17186.

15. Wang, J., Ruan, N.J., Qian, L., Chen, F., Luo, Z.G.*(2008) Wnt/β-catenin signaling suppresses rapsyn expression and inhibits AChR clustering at the neuromuscular junction. J. Biol. Chem. 283: 21668-21675.

16. Zhang, X., Zhu, J., Yang, G.Y., Wang, Q.J., Qian, L., Chen, Y.M., Chen, F., Tao, Y., Hu, H.S., Wang, T., and Luo, Z.G.*(2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol. 9, 743-754. (Highlighted by News and Views in the same issue of Nat. Cell Biol., “Faculty of 1000 Biology”, and Nature China).

17. Chen, F., Qian, L., Yang, Z.H., Huang, Y., Ngo, S.T., Ruan, N.J., Wang, J., Schneider, C., Noakes, P.G., Ding, Y.Q., Mei, L., and Luo, Z.G.* (2007) Rapsyn interaction with Calpain stabilizes AChR clusters at the neuromuscular junction. Neuron 55: 247-260. (Highlighted by “Faculty of 1000 Biology”).

18. Chen, Y.M., Wang, Q.J., Hu, H.S.,Yu, P.C., Zhu, J., Drewes, G., Piwnica-Worms, H., Luo, Z.G.* (2006) Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/aPKC complex in regulating hippocampal neuronal polarity. Proc. Natl. Acad. Sci. USA 103: 8534-8539.