|Dr. Shuijin received a B.A. degree in Biochemistry in 2000 from Lanzhou University and obtained a M.S. degree in Biophysics in 2003 from University of Science and Technology of China. He earned a Ph.D degree in Neuroscience in 2010 from Uniformed Services University of the Health Sciences in Maryland, US. He completed his postdoc training in 2015 at Memorial Sloan-Kettering Cancer Center in New York, US. He joined School of Life Sciences and Technology at ShanghaiTech University as an assistant professor, PI since 2015.|
|The mammalian neocortex progressively develops in a precise chronological order. Our main research interest is to understand the development of different neural activities in the embryonic neocortex and their roles in the formation of highly specific neuronal circuits of the adult mammalian neocortex. Currently, we particularly focus on the role of gap junction (electrical synapse) in the developing neocortex and the molecular mechanisms for gap junction formation. In addition, we are also interested in exploring the possibility of the utility of endogenous adult neural stem cells in the hippocampal dentate gyrus for a treatment of the temporal lobe epilepsy. We investigate these unanswered questions using a combination of experimental approaches including multiple-electrode whole-cell recordings, optogenetics, molecular cell biology, and imaging.|
1. He S, Li Z, Ge S, YuY-C, Shi S-H (2015) Inside-out radial glial migration facilitateslineage-dependent microcircuit assembly in the neocortex. Neuron 86(5):1159-66.
2. Xu H-T, Han Z, Gao P, He S, Li Z, Shi W,Kodish O, Shao W, Brown KN, Huang K and Shi S-H. (2014) Distinctlineage-dependent structural and functional organization of the hippocampus.Cell 157(7): 1552-64.
3. HeS, Bausch SB (2014) Synaptic plasticity in glutamatergic andGABAergic neurotransmission following chronic memantine treatment in an in vitro modelof limbic epileptogenesis. Neuropharmacology 77: 379-86.
4. HeS, Shao L-R, Wang Y and Bausch SB (2013) Synaptic andextrasynaptic plasticity in glutamatergic circuits involving dentate granulecells following chronic N-methyl-D-aspartate receptor inhibition. JNeurophysiol.109(6): 1535-47.
5. Yu Y-C#*, He S #*, Chen S, Fu Y, Brown KN, Yao X-H,Ma J, Gao P, Sosinsky GE, Huang K and Shi S-H* (2012) Preferential electricalcoupling regulates lineage-dependent microcircuit assembly in the neocortex.Nature 486(7401):113-7.
#,co-first; *, corresponding authors.
6. HeS, Shao L-R, Rittase WB and Bausch SB (2012) Increased Kv1channel expression may contribute to decreased sIPSC frequency followingchronic inhibition of NR2B-containing NMDAR. Neuropsychopharmacology 37(6):1338-56.
7. Bausch SB, He S, Petrova Y, WangXM, McNamara JO (2006) Plasticity of both excitatory and inhibitory synapses isassociated with seizures induced by removal of chronic blockade of activity incultured hippocampus. J Neurophysiol. 96(4):2151-67.