上海科技大学人力资源管理
ShanghaiTech University Human Resources
Gaofeng Fan    Assistant Professor, PI
Institute School of Life Science and Technology
Research Area Ovarian cancer metastasis and therapeutic resistance/Tyrosine phosphorylation/Poly-ADP Ribosylation
Contact Info. fangf@@shanghaitech.edu.cn
 
  Biography  
1999.9 - 2003.7 B.Sc., Biology, Department of Intensive Institution, Nanjing University (Advisor: Dr. Genxi Li, Professor and Chair, Biochemistry)
2003.9 - 2009.7 Ph.D., Department of Biochemistry, Rutgers University-University of Medicine and Dentistry of New Jersey (Advisor: Dr. Céline Gélinas, Professor and Associate Dean)
2009.9 - 2017.2 Postdoctoral Fellow, Cold Spring Harbor Laboratory (Advisor: Dr. Nicholas K. Tonks, Professor and Deputy Director, FRS)
2017.2 – now Assistant Professor, PI, School of Life Science and Technology, ShanghaiTech University
  Research Interests  
Ovarian cancer is the leading cause of death from gynecological malignancies and ranks fifth of all cancer-related deaths in women. To date, there is no reliable screening test for the early detection of this“silent”killer disease, and less than 35% of women are diagnosed before Stage III, with five-year survival for Stage III or IV being less than 25%. Improvement in treatment is an urgent need for this devastating disease.
Despite recent advances in surgery, the overall survival from ovarian cancer has not improved significantly for last four decades. Failure in early detection results in disease progression to an advanced stage with metastasis. It has been shown that approximately 70% of patients presents with disease that has spread beyond the ovaries. It is almost impossible to render patients free of disease with surgery due to this diffuse feature. Therefore, our efforts to pinpoint the molecular basis for ovarian carcinoma dissemination and metastasis hold great promise to provide information that will lead to development of next generation chemotherapeutical drugs that can effectively inhibit these events after surgery.
Another major impediment to successful treatment of ovarian cancer is acquired resistance to therapy. Platinum-based chemotherapeutics combined with Taxol is the conventional treatment for ovarian cancer after surgery. However, no matter how meticulously designed the chemotherapy regimen it is, relapse remains almost inevitable in patients with advanced disease. With the improvement of our understanding of the pathological features of this heterogeneous disease, the concept of targeted therapy has led to a series of pre-clinical and clinical trails, including targeting VEGF, EGF and PDGF signaling, separately or in combination, PARP inhibition in BRCA-deficient context, and inactivation of downstream pathway PI3K-AKT. Encouraging results have been reported, especially for anti-angiogenic and anti-PARP therapies; however, acquired resistance significantly lowers treatment efficacy and still remains as the primary issue to be addressed.
My lab will integrate both biochemical and biological approaches to address these two urgent issues in ovarian cancer treatment. We will also apply high-throughput screen to identify leading compound(s) against novel and druggable target(s) revealed from our studies.
  Selected Publications  

1.     JialiZhang, Zuo Wang, Siwei Zhang, Yanxun Chen, Xuexue Xiong, XiaojuanLi, Nicholas K. Tonks* and Gaofeng Fan*. SpatialRegulation of Signaling by the Coordinated Action of the Protein TyrosineKinases MET and FER. CellularSignalling (2018) (Epub ahead ofprint)

 

2.     Xiang-Ping Yao#, Xuewen Cheng#, ChongWang#, Miao Zhao#, Xin-Xin Guo, Hui-Zhen Su, Lu-Lu Lai, Xiao-Huan Zou, Xue-Jiao Chen, Yuying Zhao, En-LinDong,Ying-Qian Lu, Shuang Wu, Xiaojuan Li, GaofengFan, HongjieYu, Jianfeng Xu, Ning Wang*, Zhi-Qi Xiong*, Wan-Jin Chen*. Biallelicmutations in KIAA1161 cause autosomal recessive primary familial braincalcification. Neuron (2018) Jun 27;98(6):1116-1123

 

3.     Gaofeng Fan. FER mediated HGF-independent regulation of HGFR/MET activatesRAC1-PAK1 pathway to potentiate metastasis in ovarian cancer. SmallGTPase (2017) Nov 3:1-5

 

4.     Siwei Zhang, Gaofeng Fan, Yuan Hao, MollyHammell, John Erby Wilkinson, Nicholas K Tonks. Suppression of protein tyrosinephosphatase N23 predisposes to breast tumorigenesis via activation of FYNkinase. Genes & Development (2017) 31(19):1939-1957 – Selected as “Cover story”

 

5.     WanjingShang*, Fei Wang*, Gaofeng Fan#,Haopeng Wang#. Key elements for designing and performing a CRISPR/Cas9-basedgenetic screen. Journal of Geneticsand Genomics (2017)44(9):439-449. (#co-corresponding author)

 

6.     PrajwalGurung*, GaofengFan*, John R. Lukens, Peter Vogel, Nicholas K. Tonks and Thirumala-DeviKanneganti. Tyrosine Kinase SYK licenses MyD88 Adaptor Protein to InstigateIL-1a-Mediated Inflammatory Disease. Immunity (2017)46(4), 635-648 (*co-first author)

 

7.     Gaofeng Fan,Siwei Zhang, Yan Gao, Peter A. Greer and and Nicholas K. Tonks. HGF-independentRegulation of MET and GAB1 by Non-Receptor Tyrosine Kinase FER PotentiatesMetastasis in Ovarian Cancer. Genes & Development (2016) 30 (13), 1542-1557

 

8.     GaofengFan*, Saadat Aleem*, Ming Yang, W. Todd Miller and Nicholas K.Tonks. Protein Tyrosine Phosphatase andKinase Specificity in Regulation of SRC and BRK. Journal of Biological Chemistry (2015) 288 (34), 24923-24934 - Selected as “Paper of the week

 

9.     GaofengFan*, Kazimierz O. Wrzeszczynski*, Cexiong Fu, Gang Su, Scott R.Powers, Darryl J. Pappin, Robert Lucito and Nicholas K. Tonks. A quantitativeproteomics-based signature of platinum sensitivity in ovarian cancer celllines. Biochemical Journal (2015) 465(3):433-42

 

10.   Gaofeng Fan,Guang Lin, Robert Lucito and Nicholas K. Tonks. Protein-tyrosine Phosphatase 1B­Antagonized Signaling by Insulin-like Growth Factor-1 Receptor and kinaseBRK/PTK6 in Ovarian Cancer Cells. Journal of Biological Chemistry (2013) 288(34): 24923-34 - Selected as “Paper of the week

 

11.   GaofengFan*, Matthew J. Simmons*, Sheng Ge, Jui Dutta-Simmons, Jerome F.Kucharczak, Yacov Ron, David Weissmann, Chiann-Chyi Chen, Chandreyee Mukherjee,Eileen White and Celine Gelinas. Defective ubiquitin-mediated degradation of antiapoptotic Bfl-1 predisposes tolymphoma. Blood (2010) 115(17):3559-69 - Recommended by “Faculty of1000”

 

12.   GaofengFan, Yongjun Fan, Nupur Gupta, Isao Matsuura, Fang Liu, Xiao zhenZhou, Kun Ping Lu and Celine Gelinas. The Peptidyl-Prolyl IsomerasePIN1 markedly enhances the oncogenic activity of the Rel protein subunits ofNF-kB. Cancer Research (2009)69(11): 4589-97

 

13.   JuiDutta, Gaofeng Fan and CelineGelinas. CAPERa is a novelRel-TAD-interacting factor that inhibits lymphocyte transformation by thepotent Rel/NF-kBoncoprotein v-Rel. Journal of Virology (2008)82(21): 10792-802

 

14.   Nupur Gupta, Jeffrey Delrow, AmarDrawid, Anirvan M. Sengupta, GaofengFan and Celine Gelinas. Repression of B-cell linker (BLNK) andB-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocytetransformation by rel proteins. Cancer Research (2008) 68(3): 808-14

 

15.   Younjun Fan*, Jui Dutta*, NupurGupta*, Gaofeng Fan*and Celine Gelinas. Regulation of programmed cell death by NF-kB and itsrole in tumorigenesis and therapy. Review. Adv Exp MedBiol (2008)615:223-50 (*co-first author)

 

16.   Matthew J. Simmons, Gaofen Fan,Weixin Zong, Kurt Degenhardt, Eileen White and Celine Gelinas. Bfl-1/A1functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene (2008) 27(10): 1421-8

 

17.   Jui Dutta*, Yongjun Fan*, NupurGupta*, Gaofeng Fan* and CelineGelinas. Current insights into the regulation of programmed cell death by NF-kB. Review. Oncogene (2006)25(51): 6800-16 (*co-first author)

 

18.   Xinjian Liu, Yinxi Huang, WenjunZhang, Gaofeng Fan,Chunhai Fan and Genxi Li. Electrochemical investigation of redox thermodynamicsof immobilized myoglobin: ionic and ligation effects. Langmuir (2005) 21(1):375-8