上海科技大学人力资源管理
ShanghaiTech University Human Resources
Sachdev S. Sidhu    Distinguished Adjunct Professor
Institute SIAIS
Department of Medical Research, University of Toronto
Research Area biochemistry
Contact Info. sachdev.sidhu@@utoronto.ca
 
  Research Interests  
Combine phage display and high-throughput screening and sequencing technology to study protein structure and function
  Selected Publications  
1.A Strategy for Modulation of Enzymes in the Ubiquitin System. Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J.R., Neculai, A.M., Neculai, D., Vorobyov, A., Garg, P., Beatty, L., Chan, P.K., Juang, Y.C., Landry, M.C., Yeh, C., Zeqiraj, E., Karamboulas, K., Allali-Hassani, A., Vedadi, M., Tyers, M., Moffat, J., Sicheri, F., Pelletier, L., Durocher, D., Raught, B., Rotin, D., Yang, J., Moran, M.F., Dhe-Paganon, S., Sidhu, S.S. Science. 2013; 339, 590-5.
2.Inhibition of Wnt/b-catenin signaling by peptides that target dishevelled PDZ domains. Zhang, Y., Appleton, B.A., Wiesmann, C., Lau, T., Costa, M., Hannoush, R. N., Sidhu, S.S. Nat. Chem. Biol. 2009; 5, 217-9.
3.A specificity map for the PDZ domain family. Tonikian, R., Zhang, Y., Sazinsky, S.L., Currell, B., Yeh, J.-H., Reva, B., Held, H.A., Appleton, B.A., Evangelista, M., Wu, Y., Xin, X., Chan, A.C., Seshagiri, S., Sander, C., Lasky, L.A., Boone, C., Bader, G.D. Sidhu, S.S. PLoS Biol. 2008; 6, e239.
4.Synthetic therapeutic antibodies. Sidhu, S.S., Fellouse, F.A. Nat. Chem. Biol. 2006, 12, 682-8.