|Dr. Wenqing Shui graduated from Fudan University (Shanghai, China) with a master degree in 2004 and received Ph.D. at University of California (Berkeley, U.S.A.) with Dr. Carolyn Bertozzi and Dr. Jay Keasling in 2009. After her postdoctoral training at Thermo Fisher Scientific (San Jose, USA) as a bio-mass spectrometry application scientist, she joined School of Life Sciences in Nankai University (Tianjin, China) as Associate Professor from 2009 to 2013. Then she worked as Professor at Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences from 2013 to 2016. Since April 2016, she joined iHuman Institute in ShanghaiTech University as Research Associate Professor (tenure-track).|
The main goal of Shui research group is to develop versatile mass spectrometry (MS)-based technologies for GPCR ligand discovery and cell signaling study. Over the years, our group has gained extensive experiences in developing high resolution mass spectrometry-centered analytical pipelines for comprehensive or targeted protein and metabolite analysis. Our expertise in proteomics and metabolomics research has been exploited to establish affinity mass spectrometry technology for ligand screening towards protein targets of therapeutic importance. These new approaches have unique advantages in building a high-throughput screening platform for early-phase drug discovery as well as probingreceptor-drug interactions and signaling selectivity within the cell.
Shui laboratory website:http://shuilab.ihuman.shanghaitech.edu.cn/
1. Zhang B, Zhao S, Yang D, Wu Y, Xin Y, Cao H, Huang X, Cai X, Sun W, Ye N, Xu Y, Peng Y, Zhao S, Liu Z, Zhong G, Wang M, Shui W. A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts. ACS Central Science 2020, 6, 213-225.
2. Lou R, Tang P, Ding K, Li S, Tian C, Li Y, Zhao S, Zhang Y, Shui W. Hybrid spectral library combining DIA-MS data and a targeted virtual library substantially deepens the proteome coverage. iScience 2020，23, 100903.
3. Li SS, Shui W. Systematic mapping of protein-metabolite interactions with mass spectrometry-based techniques. Current Opinion in Biotechnology2019, 64, 24-31.
4.Lu Y, Qin S, Zhang B, Dai A, Cai X, Ma M, Gao ZG, Yang D, Stevens RC, Jacobson KA, Wang MW, Shui W. Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor. Analytical Chemistry 2019, 91, 8162-8169.
5. Qin S, Meng M, Yang D, et al., Shui W. High-throughput Identification of G Protein-coupled Receptor Modulators through Affinity Mass Spectrometry Screening.Chemical Science 2018, 9, 3192-3199.
6. Li Z, Li Y, Chen W, et al., Shui W. Integrating MS1 and MS2 Scans in High-Resolution Parallel Reaction Monitoring Assays for Targeted Metabolite Quantification and Dynamic 13C-Labeling Metabolism Analysis. Analytical Chemistry 2017, 89, 1, 877-885.
7. Xiong Y, Guo Y, Xiao W, et al., Shui W. An NGS-Independent Strategy for Proteome-Wide Identification of Single Amino Acid Polymorphisms by Mass Spectrometry. Analytical Chemistry 2016, 88, 5, 2784-2791.