上海科技大学人力资源管理
ShanghaiTech University Human Resources

Ying Xi    Assistant Professor, PI

Institute

 School of Life Science and Technology

Research Area

 Lung stem cell, regeneration and lung fibrosis

Contact Info.

 xiying@@shanghaitech.edu.cn

  

 

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Biography

 

 

Dr. Xi received her   BS degree in Biology from Nanjing University (2003), and her PhD degree in   Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry   and Cell Biology, Chinese Academy of Sciences (2010). She did her postdoctoral training   in the Department of Medicine at University of California, San Francisco (2010-2016), and   worked in the Department of Immunology at Genentech Inc. as Senior   Scientific Researcher (2016-2019). In August 2019, she joined School of Life   Science and Technology at ShanghaiTech University as an Assistant Professor,   PI.

 

 

Research Interests

 

 

Tissue fibrosis (scarring)   occurs as a complication of many major human diseases and is a leading cause   of morbidity and mortality worldwide. The 5-year survival rates for patients   with progressive fibrotic diseases, e.g. idiopathic pulmonary fibrosis (IPF) are   worse than many types of cancer. However, fibrosis is poorly understood, and   accordingly, IPF   remains an urgent unmet medical need despite two FDA-approved therapies, each   of which show limited efficacy.

 

Fibrotic scarring is often   defined as a wound-healing response that has gone awry. The adult lung   is a largely quiescent tissue, but it can respond robustly to injury to   regenerate lost or damaged cells, by activating stem/progenitor populations   or promoting surviving, mature lineages to re-enter the cell cycle. When this   regenerative potential is disrupted or limited, fibrosis may occur. Therefore,   understanding the reparative   capacity of the lung and the regulation of resident stem/progenitor   cells in response to tissue injury is of remarkable therapeutic interest.

 

Our lab uses in   vitro and in vivo systems, including organoid culture,   cell-lineage tracing, and fibrosis animal models, combined with transcriptome   analysis to the characterize the molecular mechanisms that regulate   stem/progenitor cell proliferation and differentiation. Our ultimate goal is to   identify genetic, molecular and cellular therapies for the treatment of   fibrotic diseases.

 

 

 

Selected Publications

 

1.      Xi Y, Kim T, Brumwell AN, Driver I, Wei Y, Tan V,   Jackson J, Xu J, Lee DK, Gotts J, Matthay M, Shannon JM, Chapman HA, Vaughan AE. Local lung   hypoxia determines epithelial fate decisions during alveolar regeneration. Nat   Cell Biol 2017,19(8): 904-14.   

Highlighted in Nat Cell Biol: “Origin and   regulation of a lung repair kit”.

 

2.      Kanegai C, Xi   Y, Donne M, Gotts J, Driver I, Lechner A, Jones K, Vaughan AE, Chapman   HA, Rock J. Persistent pathology in influenza infected mouse lungs. Am J Respir Cell Mol Biol2016, 55(4): 613-5.

 

3.   Vaughan AE, BrumwellAN, XiY, Gotts J, BrownfieldDG, TreutleinB, Tan K, Tan V, Liu FC, Looney MR, MatthayM, RockJ, ChapmanHA. Lineage-negative   progenitor cells mobilize to regenerate lung epithelium after major injury. Nature   2015, 517 (7536): 621-5.

Highlighted   in Nature: “Stem cells: Emergency back-up for lung repair”.

 

4.   Xu   PL, Bailey-Bucktrout S,Xi Y, Xu DQ, Du D, Zhang Q, Xiang WW,   Liu JM, Melton A, Sheppard D, Chapman HA,   Bluestone JA, Derynck R. Innate   antiviral host defense attenuates TGF-b function through   IRF3-mediated suppression of Smad signaling.Mol Cell2014, 56 (6): 723-7.

   Highlighted in Mol Cell: “Resemble and Inhibit:   When RLR Meets TGF-b”.

 

5.      Xi Y, Tan K, Brumwell AN, Chen S, Kim YH, Kim TJ,   Wei Y, Chapman HA. Inhibition of epithelial to mesenchymal transition and   pulmonary fibrosis by methacycline.Am J Respir Cell Mol Biol2014,   50 (1): 51-60.

 

6.      Xi Y*, Wei Y*,   Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM,   Jablons DM,Chapman HA.Identification of pY654-b-catenin as a critical co-factor in hypoxia-inducible factor-1asignaling and   tumor responses to hypoxia. Oncogene   2013, 32 (42): 5048-57. * co-first author

 

7.      Ulsamer   A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. Axin   pathway activity regulates in vivo pY654-b-catenin accumulation and pulmonary   fibrosis. J Biol Chem2012,287 (7):   5164-72.

 

8.      Chen   T*, Li M*, Ding Y, Zhang LS, Xi Y,   Pan WJ, Tao DL, Wang JY, Li L. Identification of zinc-finger BED   domain-containing 3 (Zbed3) as a novel Axin-interacting protein that   activates Wnt/b-catenin signaling. J   Biol Chem2009, 284   (11): 6683-9.

 

9.      Ding   Y*, Xi Y*, Chen T, Wang JY, Tao   DL, Wu ZL, Li YP, Li C, Zeng R, Li L. Caprin-2 enhances canonical Wnt   signaling through regulating LRP5/6 phosphorylation. J Cell Biol   2008, 182 (5): 865-72.

 

10. Gan XQ*, Wang JY*, Xi Y, Wu ZL, Li YP, Li L. Nuclear Dvl, c-Jun, b-catenin, and TCF form a complex leading   to stabilization of b-catenin-TCF interaction.J Cell Biol   2008, 180 (6): 1087-100. 

   Recommended by Faculty of 1000.