Ying Xi Assistant Professor, PI
Dr. Xi received her BS degree in Biology from Nanjing University (2003), and her PhD degree in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (2010). She did her postdoctoral training in the Department of Medicine at University of California, San Francisco (2010-2016), and worked in the Department of Immunology at Genentech Inc. as Senior Scientific Researcher (2016-2019). In August 2019, she joined School of Life Science and Technology at ShanghaiTech University as an Assistant Professor, PI.
Tissue fibrosis (scarring) occurs as a complication of many major human diseases and is a leading cause of morbidity and mortality worldwide. The 5-year survival rates for patients with progressive fibrotic diseases, e.g. idiopathic pulmonary fibrosis (IPF) are worse than many types of cancer. However, fibrosis is poorly understood, and accordingly, IPF remains an urgent unmet medical need despite two FDA-approved therapies, each of which show limited efficacy.
Fibrotic scarring is often defined as a wound-healing response that has gone awry. The adult lung is a largely quiescent tissue, but it can respond robustly to injury to regenerate lost or damaged cells, by activating stem/progenitor populations or promoting surviving, mature lineages to re-enter the cell cycle. When this regenerative potential is disrupted or limited, fibrosis may occur. Therefore, understanding the reparative capacity of the lung and the regulation of resident stem/progenitor cells in response to tissue injury is of remarkable therapeutic interest.
Our lab uses in vitro and in vivo systems, including organoid culture, cell-lineage tracing, and fibrosis animal models, combined with transcriptome analysis to the characterize the molecular mechanisms that regulate stem/progenitor cell proliferation and differentiation. Our ultimate goal is to identify genetic, molecular and cellular therapies for the treatment of fibrotic diseases.
1. Xi Y, Kim T, Brumwell AN, Driver I, Wei Y, Tan V, Jackson J, Xu J, Lee DK, Gotts J, Matthay M, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol 2017,19(8): 904-14.
Highlighted in Nat Cell Biol: “Origin and regulation of a lung repair kit”.
2. Kanegai C, Xi Y, Donne M, Gotts J, Driver I, Lechner A, Jones K, Vaughan AE, Chapman HA, Rock J. Persistent pathology in influenza infected mouse lungs. Am J Respir Cell Mol Biol2016, 55(4): 613-5.
3. Vaughan AE, BrumwellAN, XiY, Gotts J, BrownfieldDG, TreutleinB, Tan K, Tan V, Liu FC, Looney MR, MatthayM, RockJ, ChapmanHA. Lineage-negative progenitor cells mobilize to regenerate lung epithelium after major injury. Nature 2015, 517 (7536): 621-5.
Highlighted in Nature: “Stem cells: Emergency back-up for lung repair”.
4. Xu PL, Bailey-Bucktrout S,Xi Y, Xu DQ, Du D, Zhang Q, Xiang WW, Liu JM, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-b function through IRF3-mediated suppression of Smad signaling.Mol Cell2014, 56 (6): 723-7.
Highlighted in Mol Cell: “Resemble and Inhibit: When RLR Meets TGF-b”.
5. Xi Y, Tan K, Brumwell AN, Chen S, Kim YH, Kim TJ, Wei Y, Chapman HA. Inhibition of epithelial to mesenchymal transition and pulmonary fibrosis by methacycline.Am J Respir Cell Mol Biol2014, 50 (1): 51-60.
6. Xi Y*, Wei Y*, Sennino B, Ulsamer A, Kwan I, Brumwell AN, Tan K, Aghi MK, McDonald DM, Jablons DM,Chapman HA.Identification of pY654-b-catenin as a critical co-factor in hypoxia-inducible factor-1asignaling and tumor responses to hypoxia. Oncogene 2013, 32 (42): 5048-57. （* co-first author）
7. Ulsamer A, Wei Y, Kim KK, Tan K, Wheeler S, Xi Y, Thies RS, Chapman HA. Axin pathway activity regulates in vivo pY654-b-catenin accumulation and pulmonary fibrosis. J Biol Chem2012,287 (7): 5164-72.
8. Chen T*, Li M*, Ding Y, Zhang LS, Xi Y, Pan WJ, Tao DL, Wang JY, Li L. Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/b-catenin signaling. J Biol Chem2009, 284 (11): 6683-9.
9. Ding Y*, Xi Y*, Chen T, Wang JY, Tao DL, Wu ZL, Li YP, Li C, Zeng R, Li L. Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation. J Cell Biol 2008, 182 (5): 865-72.
10. Gan XQ*, Wang JY*, Xi Y, Wu ZL, Li YP, Li L. Nuclear Dvl, c-Jun, b-catenin, and TCF form a complex leading to stabilization of b-catenin-TCF interaction.J Cell Biol 2008, 180 (6): 1087-100.
Recommended by Faculty of 1000.