上海科技大学人力资源管理
ShanghaiTech University Human Resources

Jian Zhao    Associate Professor, PI

Institute

Shanghai Institute for Advanced Immunochemical Studies (SIAIS), School of Life Science and Technology

Research Area

Basic researchNew mechanisms, new drug targets and new therapeutic strategies     against dementia

Translational Research:

a GLP/GMP/GCP integrated cell     manufactory system providing end-to-end solution for cell manufacturing and     related clinical trials

Contact Info.

zhaojian @@shanghaitech.edu.cn

 

http://hr.shanghaitech.edu.cn/_upload/article/images/1c/7c/358712f64b8db7d05432c83e647e/b45ca59b-085c-401d-a986-4eee0d649236.jpg

 

 

Biography

 

 

Education

Fudan   University, Shanghai, China - BS, Genetics    -   1996

Shanghai   Institute of Cell Biology, Chinese Academy of Sciences - MS, Cell Biology    - 1999

The   Ruperto-Carola University of Heidelberg, Germany - PhD, Cell Biology    - 2004

German   Cancer Research Center, Germany- Post   Doctoral Fellowship, Cell Biology - 2004~2007

Professional Positions

Associate Professor, PI - Shanghai Institute for Advanced   Immunochemical Studies (SIAIS), School of Life Science and Technology,   ShanghaiTech University, Shanghai                             03/2019   - Present

Professor -   School of Medicine, Institute for Advanced Study, Tongji University, Shanghai                                            03/2016   - 02/2019

Director -   Stem cell core facility, Shanghai East Hospital, Tongji University School of   Medicine                                06/2015   - 07/2018

Associate   Professor - Lab of Cell Signaling, Institute of Biochemistry and cell   biology, Shanghai Institutes for Biology Sciences (SIBS), Chinese Academy of   Sciences (CAS)                                                     02/2007   - 02/2016

Assistant   Research Professor - Young Scientists Group, Max-Planck Guest Laboratory,   Shanghai Institute of Cell Biology, Chinese Academy of Sciences                                                                       07/1996   - 09/2000

 

 

Research Interests

 

 

In more than a decade of research, I have focused on the study of new   mechanisms of important signal transduction pathways in cell fate   determination as well as in the pathogenesis and progression of neurodegenerative   diseases. Our major findings include:

1. Established a novel chemical-induced transdifferentiation technology,   providing induced human neural (progenitor) cells for disease-modeling. A   series of in vitro small molecule transdifferentiation induction systems were   established, and the possible general formula of transdifferentiation was   proposed, by which exploration of the regulatory mechanisms of   neurodegenerative diseases with human cells become possible.

2. Elucidated that the secretase protein complex as the key   regulators of the development and progression of the Alzheimer’s diseases,   providing a unique path for finding novel drugs that affects Aβ production   and metabolism by various signal transduction proteins or protein complexes   on the cell surface. We found that cell surface receptors, secretases and   their regulatory proteins form functional secretase protein complexes   (holo-secretase complex). Our results show that assembly of these secretase   complex mediates the production of pathogenic β-amyloid, whereas intervention   of which retards the generation of β-amyloid and Alzheimer's disease process.   Our studies not only reveal new regulatory molecules in AD pathogenesis but   propose new therapeutic strategies against the disease.

Our efforts will continue to focus on elucidating new mechanisms of key   signal transduction pathways mediating the pathogenesis and progression of   neurodegenerative diseases based on our previous achievements.

Direction I.  Generating induced   human neural (progenitor) cells as disease-modeling system.

Direction II. Cellular surface protein complexes as novel targets for   the Alzheimer's disease.

Direction III. Exploring the multiple etiological characteristics of   neurodegenerative diseases and new strategies for systematic treatment with   multiple targets

 

 

Selected Publications

 

 

1.         Wenxiang Hu, Binlong Qiu, Wuqiang Guan,   Qinying Wang, Min Wang, Wei Li, Longfei Gao, Lu Shen, Yin Huang, Gangcai Xie,   Hanzhi Zhao, Ying Jin, Beisha Tang, Yongchun Yu, Jian Zhao* and Gang Pei*. Direct Conversion of Normal and   Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules.   (2015) Cell Stem Cell. 17:204-12. [*Co-corresponding authors]

2.         Lin Cheng, Longfei Gao, Wuqiang Guan,   Jianxin Mao, Wenxiang Hu, Binlong Qiu, Jian   Zhao, Yongchun Yu and Gang Pei. Direct conversion of astrocytes into   neuronal cells by drug cocktail (2015) Cell Res. 25:1269–1272.

3.         Jin Cui, Xiaoyin Wang, Xiaohang Li, Xin   Wang, Chenlu Zhang, Wei Li, Yangming Zhang, Haifeng Gu, Xin Xie, Fajun Nan, Jian Zhao* and Gang Pei*. Targeting   the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates   Alzheimer’s disease-related pathogenesis. (2015) Cell Discovery 1:15021.   [Co-corresponding authorship and Co-first authorship]

4.         Jianxin Mao, Shichao Huang, Shangfeng Liu,   Xiao-Lin Feng, Miao Yu, Junjun Liu, Yi Eve Sun, Guoliang Chen, Yang Yu, Jian Zhao* and Gang Pei1*. A herbal   medicine for Alzheimer's disease and its active constituents promote neural   progenitor proliferation. (2015) Aging Cell. 14(5):784-96   [*Co-corresponding authors]

5.         Xin Wang, Jin Cui, Wei Li, Xianglu Zeng, Jian Zhao* and Gang Pei*. γ-secretase   modulators and inhibitors induce different conformational changes of   presenilin 1 revealed by FLIM and FRET. (2015) Journal of Alzheimer’s Disease   47:927-37 [*Co-corresponding authors]

6.         Lin Cheng, Wenxiang Hu, Binlong Qiu, Jian Zhao*, Yongchun Yu, Wuqiang   Guan, Min Wang, Wuzhou Yang and Gang Pei*. Generation of neural progenitor   cells by chemical cocktails and hypoxia. (2014) Cell Res. 24:665-7 [Co-corresponding   authorship and Co-first authorship]

7.         Yujun Hou, Ying Wang, Jian Zhao*, Xiaohang Li, Jin Cui, Jianqing Ding, Ying Wang,   Xianglu Zeng, Yun Ling, Xiaoheng Shen, Shengdi Chen, Chenggang Huang and Gang   Pei*. Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid   Pathology and Related Cognitive Deficits (2014) PLoS ONE (2014),   9(11):e111215. [Co-corresponding authorship and Co-first authorship]

8.         Wenxiang Hu, Jian Zhao* and Gang Pei*. Activation of aryl hydrocarbon receptor   by Tranilast, an anti-allergy drug, promotes miR-302 expression and cell   reprogramming. (2013) J Biol Chem. 288: 22973-84   [*Co-corresponding authors]

9.         Xiaosong Liu, Xiaohui Zhao, Xianglu Zeng,   Koen Bossers, Dick F. Swaab, Jian   Zhao* and Gang Pei*. β-Arrestin1 regulates γ-secretase complex assembly   and modulates amyloid-β pathology. (2013) Cell Res.,23:351-65. [*Co-corresponding authors]

10.     Jian Zhao and Gang Pei. Arrestins in metabolic   regulation. (2013) Prog Mol Biol Transl Sci.   118:413-27. (Review) 

11.     Xiaosong Liu and Jian Zhao. GPCR, a rider of Alzheimer’s disease. (2011) Frontiers   in Biol. 6: 282-288. (Review)     

12.     Jian Zhao and Gang Pei. Why Cell Reprogramming is   Functionally Linked to Aging? (2011) Aging, 3(8) (Review)