上海科技大学人力资源管理
ShanghaiTech University Human Resources

Ning Zhou    Research Associate Professor, PI

Institute

iHuman Institute

Research Area

Neurobiology; brain disease mechanisms

Contact Info.

zhouning@@shanghaitech.edu.cn

 

 

 

Biography

 

 

1998-2002         BSc, Peking University, China

2003-2010         PhD, University of British Columbia, Canada

2010-2011         Postdoctoral fellow, University of British Columbia, Canada

2011-2019           Assistant Professor, Investigator, China Medical University, Taiwan

2019-present      iHuman Institute, ShanghaiTech University

 

 

Research Interests

 

 

Functional alterations in neuronal activity are at the pathological root of many brain disorders. My overarching research goal is to understand how neuronal
function is disrupted by neurological and mental disorders at the cellular and network level. Using techniques of two-photon fluorescence imaging, in vivo
Ca2+ imaging with miniature endoscopes, and patch clamp recordings, our research focuses on the following topics: (1) functional alterations of local
neuronal networks in normal and diseased brain; (2) interaction between neurons and glial cells; and (3) electrophysiological and neurovascular changes
following spreading depolarization and acute brain injuries.

 

 

Selected Publications

 

 

1.    Mei YY, Wu DC, Zhou N*. (2018) Astrocytic Regulation of Glutamate Transmission in Schizophrenia. Front Psychiatry. doi: 10.3389/fpsyt.2018.
00544.

2.    Wu DC, Chen RY, Cheng TC, Chiang YC, Shen ML, Hsu LL, Zhou N*. (2018) Spreading Depression Promotes Astrocytic Calcium Oscillations and Enhances Gliotransmission to Hippocampal Neurons. Cerebral Cortex, 38(11):2818-2831.

3.    Wang CH, Hernandez CC, Wu J, Zhou N, Hsu HY, Shen ML, Wang YC, Macdonald RL and Wu DC. (2018) A missense mutation A384P associated with human hyperekplexia reveals a desensitization site of glycine receptors. Journal of Neuroscience, 38(11):2818-2831.

4.    Lin CH, Hsu SP, Cheng TC, Huang CW, Chiang YC, Hsiao IH, Lee MH, Shen ML, Wu DC, Zhou N*. (2017) Effects of anti-epileptic drugs on
spreading depolarization-induced epileptiform   activity in mouse hippocampal slices.
Scientific Reports, (1)11884.

5.    Shen ML, Wang CH, Chen RY, Zhou N*, Kao ST*, Wu DC*. (2016) Luteolin inhibits GABAA receptors in HEK cells and brain slices. Scientific
Reports
, (6)27695.

6.    Rosenegger DG, Tran CH, LeDue J, Zhou N, Gordon GR. (2014) A high performance, cost-effective, open-source microscope for scanning two-
photon microscopy that is modular and readily adaptable.
PLoS One. 9(10):e110475.

7.    Zhou N, Wang CH, Zhang S, Wu DC. (2013) The GLRA1 Missense Mutation W170S Associates Lack of Zn2+ Potentiation with Human
Hyperekplexia.
Journal of Neuroscience, 33(45):17675-81.

8.    Zhou N, Rungta RL, Malik A, Han H, Wu DC, MacVicar BA. (2013) Regenerative glutamate release by presynaptic NMDA receptors contributes to
spreading depression.
Journal of Cerebral Blood Flow & Metabolism, 33(10):1582-94.

9.    Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA
(2012). Metabolic communication between neurons and astrocytes via bicarbonate-responsive soluble adenylyl cyclase.
Neuron, 75(6):1094-1104.  

10.Zhou N, Gordon GRJ, Feighan D, MacVicar BA (2010) Transient swelling, acidification and   mitochondrial depolarization occurs in neurons but not
astrocytes during spreading depression.
Cerebral Cortex, 20 (11): 2614-2624.

11.Thompson RJ, Zhou N, MacVicar BA (2006) Ischemia opens neuronal gap junction hemichannels. Science, 312:924-927.

12.Brust TB, Cayabyab FS, Zhou N, MacVicar BA (2006) p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus. The Journal of Neuroscience. 26: 12427-12438.