上海科技大学人力资源管理
ShanghaiTech University Human Resources

Wenqing Xu     Professor

Institute

School of Life Science and Technology

Research Area

Structural and mechanistic studies of cell signaling

Contact Info.

xuwq2@@shanghaitech.edu.cn

 

 

 

Biography

 

 

Dr. Wenqing Xu received his BS degree from the University of Science and Technology of China (USTC) in 1985, and his Ph. D. degree from Massachusetts Institute of
Technology (MIT) in 1995. After completing his postdoctoral training as an Irvington Fellow at the Harvard Medical School, he became a tenure-track assistant professor
at the University of Washington School of Medicine (in Seattle) in March 1999, where he was promoted to tenured associate professor and tenure full professor positions
(in 2004 and 2009, respectively). After working at University of Washington as a PI for over 20 years, he joined the ShanghaiTech University as a tenured full professor in
late August 2019. Dr. Wenqing Xu is also the director of the National Facility for Protein Science in Shanghai (NFPS).

 

 

Research Interests

 

 

In all life forms, cells must be able to perceive and correctly respond to their environment. In humans, dysregulation of cell signaling pathways can lead to many diseases including cancers. We aim to understand how cells sense their environment and transduce signals in cells under normal and pathologic conditions, using a combination of
structural (X-ray crystallographic and cryo-EM) and biochemical studies. In particular, we are interested in the Wnt signaling   pathway, which plays critical roles in
embryonic development, stem cell homeostasis and tissue regeneration. Our work helps to lay the foundation for developing novel therapeutic approaches for disease
treatment.

 

 

Selected Publications

 

 

1. Ma D, Wang Z, Merrikh CN, Lang KS, Lu P, Li X, Merrikh H, Rao Z, Xu W.* (2018). Crystal structure of a membrane-bound O-acyltransferase. Nature, 562, 286-
290.
   
2. DaRosa P, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit R*, and Xu W.* (2015). Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribose) signal. 
Nature. 517(7533):223-6.        

3. Cho U, and Xu W.* (2007). Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme. Nature (Article), 445, 53-57.    

4. Graham T, Weaver C, Mao F, Kimelman D, and Xu W.* (2000). Crystal Structure of a beta-catenin/Tcf complex. Cell, 103, 885-896.  

5. Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D*. (2018). Accurate
computational de
sign of multipass transmembrane proteins. Science, 359, 1042-1046.  

6. Shen G, Ke J, Wang Z, Cheng Z, Gu X, Wei Y, Melcher K, Xu HE*, and Xu W.* (2015). Structural basis of the Norrin-Frizzled 4 interaction. Cell Research. 25, 1078-
1081
  

7. Sun W, Zhu YJ, Wang Z, Zhong Q, Gao F, Lou J, Gong W*, and Xu W.* (2013). Crystal structure of the yeast TSC1 core domain and implications for tuberous
sclerosis pathological mutations.
Nature Communications. 2013;4:2135.       

8. Wang Z, Michaud GA, Cheng Z, Zhang Y, Hinds TR, Fan E, Cong F, and Xu W.* (2012). Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE
domains suggests a general mechanism for poly(ADP-ribosyl)ation dependent ubiquitination.
Genes & Development, 26, 235-240. 

9. Morrone S, Cheng Z, Moon RT, Cong F, Xu W.* (2012).  Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate
recruitment.
PNAS, 109, 1500-1505. 

10. Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, and Xu W.* (2011). Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Nature Structural & Molecular Biology, 18, 1204-1210. 
11. Xu Z, Cetin B, Anger M, Cho U, Helmhart W, Nasmyth K*, and Xu W.* (2009). Structure and function of the PP2A-shugoshin interaction. Molecular Cell, 35, 426-
441.
     

12. Liu J, Philips B, Amaya M, Kimble J*, and Xu W.* (2008). The C. elegans Sys-1 protein is a bona fide beta-catenin. Developmental Cell, 14, 751-761.     

13. Cho U,Morrone S, Sablina AA, Arroyo JD, Hahn WC and Xu W.* (2007). Structural basis of PP2A inhibition by small t antigen. PLoS Biology, 5, 1810-1819.   

14. Sampietro S, Dahlberg CL, Cho US, Hinds TR, Kimelman D, and Xu W.* (2006). Crystal Structure of a b-catenin/BCL9/Tcf4 Complex. Molecular Cell, 24, 293-
300.
  
15. Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D and Xu W.* (2004). Crystal structure of a b-catenin/APC complex reveals a critical role for
APC phosphorylation in APC function.
Molecular Cell. 15, 523-533. (cover story).    

16. Xing Y, Clements WK, Kimelman D, and Xu W.* (2003). Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the beta-catenin destruction
complex.
Genes and Development, 17, 2753-2764. (cover story).    

17. Graham T, Clements W, Kimelman D, and Xu W.* (2002). Crystal structure of the beta-catenin/ICAT complex reveals a inhibitory mechanism of Wnt signaling
pathway.
Molecular Cell, 10, 563-571.      

18. Graham T, Ferkey D, Mao F, Kimelman D, and Xu W.* (2001). Tcf4 can specifically recognize beta-catenin using alternative conformations. Nature Structure
Biology
, 8, 1048-1052.     

19. Xu W, Harrison SC, and Eck MJ* (1997). Three-dimensional structure of the   tyrosine kinase c-Src. Nature,385, 595-602. (Article)   

20. Xu W, Rould MA, Jun S, Desplan C, and Pabo CO* (1995). Crystal structure of a paired domain-DNA complex at 2.5Å resolution reveals structural basis for Pax
developmental mutations.
Cell, 80, 639-650.