上海科技大学人力资源管理
ShanghaiTech University Human Resources

Fang Bai   Assistant ProfessorPI

Institute 

School of Life Scienceand Technology/Shanghai Institute for Advanced Immunochemical Studies

Research Area 

Drug Discoveryand Design, Theoretical Biological Physics

Contact Info.

baifang@@shanghaitech.edu.cn

 

 

 

Biography


 

 Education:

2004-2009: Dalian University of Technology, BE in Chemical Engineering   and BA in English;

2009-2014: Dalian University of Technology(Jointly educated by Shanghai   Institute of Materia Medica, Chinese Academy of Sciences);

Employment:

2014.8-2019.5 Postdoctoral Research Fellow, Rice University;

2019.5-2019.9 Assistant Professor of Research, University of Texas   Health Science Center at Houston;

2019.10-present Assistant Professor, ShanghaiTech University

 

 

Research Interests

 

 

1.      Developing computational drug discovery and   design methodologies by combining artificial intelligence algorithms and   theories of computational drug design methods, especially focusing on   fragment-based drug design, PROTACs design and large-scale conformational   sampling of proteins.

2.      Cancer drug discovery and design, mainly   targeting against tumor metastasis and immune escape.

 

 

Selected Publications

 

 

1.    A. Amir1, F. Bai1,Y. Sohn, L.   Song, S. Tamir, H. Marjault, G. Mayer, O. Karmi, P. Jennings, R. Mittlerf,   J.N. Onuchic, A. Friedler, and R. Nechushtai. The anti-apoptotic proteins   NAF-1 and iASPP interact to drive apoptosis in cancer cells. Chem.   Sci. 2019, 10: 665-673(1Co-first   Author).

2.    F. Bai, X. Pi, P. L, P. Zhou, H. Yang, X. Wang, M. Li, Z. Gao,   H. Jiang. A Statistical Thermodynamic Model for Ligands Interacting With Ion   Channels: Theoretical Model and Experimental Validation of the KCNQ2 Channel.   Front.   Pharmacol. 2018, 9:150.

3.    F. Bai, K. Liu, H. Li, J. Wang, J. Zhu, P. Hao, L. Zhu, S.   Zhang, L. Shan, W. Ma, W. Zhang, H. Li, A.M. Bode &Z. Dong. Veratraimine   modulates AP-1-depdendent gene transcription by directly binding to   programmable DNA. Nucleic Acids Res. 2017, 46:546-557.

4.      F. Bai, F. Morcos, RR. Cheng, H. Jiang and   J.N. Onuchic. Elucidating the druggable interface of protein-protein   interactions using fragment-docking and coevolutionary analysis. Proc. Natl. Acad. Sci. USA. 2016, 113: E8051–E8058.

5.      F. Bai, F. Morcos, Y.S. Sohn, Darash-Yahana   M., C.O. Rezende, C.H. Lipper, M.L. Paddock, L. Song, Y. Luo, S.H. Holt, S.   Tamir, E.A. Theodorakis, P.A. Jennings, J.N. Onuchic, R. Mittler, and R.   Nechushtai. The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as   chemotherapeutic targets in breast cancer. Proc. Natl. Acad. Sci. USA. 2015, 12: 3698-3703.

6.    F.Bai, S. Liao, J. Gu, H. Jiang, X. Wang,   H. Li. An accurate metalloprotein-specific scoring function and molecular   docking program devised by a dynamic sampling and iteration optimization   strategy. J. Chem. Inf. Model. 2015, 55: 833-847.

7.    F.Bai, Y.Xu, J.Chen, Q.Liu, J.Gu, X.Wang, J.Ma, H. Li, J.N. Onuchic, and H.Jiang.    Free energy landscape for the binding process of Huperzine A to   acetylcholinesterase.Proc. Natl. Acad. Sci. USA. 2013, 110:4273-4278.

8.    F.Bai, H. Liu, L. Ton, W. Zhou, L. Liu, Z.   Zhao, X. Liu, H. Jiang, X. Wang, H. Xie, and H. Li Discovery of novel selective inhibitors for EGFR-T790M/L858R.   Bioorg. Med. Chem.   Lett. 2012, 22:1365-1370.

9.      F.Bai, X. Liu, J. Li, H. Zhang, H. Jiang,   X. Wang, and H. Li. Bioactive Conformational Generation of Small Molecules: A   Comparative Analysis between Force-Field and Multiple Empirical Criteria   Based Methods.BMC   Bioinformatics 2010, 11:545.

10.C. Lipper, J. Stofleth, F. Bai, Y. Sohn, S. Roy, R.   Mittler, R. Nechushtai, J.N. Onuchic, P. Jennings. Redox-dependent gating of   VDAC by mitoNEET. Proc. Natl. Acad. Sci. USA. 2019, 116: 19924-19929.

11.Z. Tan, L. Xiao, M. Tang, F. Bai, J. Li, L. Li, F. Shi,   N. Li, Y. Li, Q. Du, J. Lu, X. Weng, W. Yi, H. Zhang, J. Zhou, Q. Gao, J.N.   Onuchic, A.M. Bode, X. Luo, Y. Cao. Targeting CPT1A-mediated fatty acid   oxidation sensitizes nasopharyngeal carcinoma to radiation therapy. Theranostics   2018; 8:2329-2347.

12.K. Yim, T. Prince, S. Qu, F. Bai, P. Jennings, J.N.   Onuchic, E. Theodorakis and L. Neckers Gambogic acid identifies an   isoform-specific druggable pocket in the middle domain of Hsp90β.Proc. Natl. Acad. Sci. USA. 2016, 113:E4801-E4809.

13.M. Yahana, Y. Pozniak, M. Lu, Y.   Sohn, O. Karmi, S. Tamir, F. Bai,   L. Song, P. Jennings, E. Pikarsky, T. Geiger, J.N. Onuchic, R. Mittler and R.   Nechushtai. Breast cancer tumorigenicity is dependent on high expression   levels of NAF-1 and the lability of its Fe-S clusters. Proc. Natl. Acad. Sci. USA. 2016,113:10890-10895

14.Wang, Y. Jiang, J. Ma, H. Wu, D.   Wacker, V. Katritch, G. Han, W., Liu W., Huang X-P., E. Vardy, J. McCorvy, X.   Gao, X.E. Zhou, K. Melcher, C. Zhang, F.Bai, H. Yang, L. Yang, H. Jiang, B.L.   Roth, V. Cherezov, RC. Stevens, and X.E. Xu. Structural Basis for Molecular   Recognition at Serotonin Receptors. Science, 2013, 340:610-614.