上海科技大学人力资源管理
ShanghaiTech University Human Resources

Kun Dou    Assistant Professor   PI

Institute

School of Life     Science and Technology

Research Area

Transposon biology     and epigenetic regulation

Contact Info.

doukun@@shanghaitech.edu.cn

 

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Biography

 

 

Dr.   Dou obtained her bachelor’s degree in biology from Hunan University in 2009.   She gained her Ph.D in Beijing Normal University / National Institute of   Biological Sciences, Beijing (NIBS) in 2014, where she studied epigenetic regulation.   She worked for one year in NIBS as a postdoc researcher after her Ph.D   training and started to usefruit   fly as a model organism. She worked as a postdoctoral researcher in Carnegie   Institution for Science, department of embryology (located in Johns Hopkins   university) from 2015 to 2019 to study transposon biology and epigenetic   regulation in fruit fly (Mentor, Dr. Zhao Zhang and Dr. Allan Spradling). She   joined School of Life Science and Technology in ShanghaiTech University in   Jan. 2020 as an assistant professor (Tenure-track) and PI, focusing on   epigenetic regulation and transposon biology.      

 

 

Research Interests

 

 

Transposons, also known as jumping genes, are the most abundant residents in almost all eukaryote genomes.   Activation of transposons can lead to genome instability and may cause   cancer. It was found that more than 75 human diseases can be caused by   transposon integration. For example, retrotransposon LINE1 mobilizing into the   genomic locus of APC or FVIII led to colon cancer or hemophilia,   respectively. Therefore, it is essential to study how transposon invade host   genome.

    Dr. Dous group is using fruit fly as a major model organism   to study the following mechanisms: 1) Transposon suppression by the host; 2)   Transposon propagation in the host. We will exploit the advantages of fruit   fly, including rich genetic resources, short life cycle, to facilitate our   study and to uncover new mechanisms. We are also expecting to extend our   knowledge in fruit fly to mammalian systems to better understand transposon   regulation in mammals.    

 

 

Selected Publications

 

 

1.      Lu Wang#, Kun Dou#, Sungjin Moon, Frederick J.   Tan, ZZ Zhao Zhang. (2018). Hijacking oogenesis enables massive propagation   of LINE and retroviral transposons. Cell. 2018. Aug   23;174(5):1082-1094.e12. (Equally   contributed, voluntarily to be the latter one)

2.      Dou K#, Huang CF#, Ma ZY, Zhang CJ, Zhou   JX, Huang HW, Cai T, Tang K, Zhu JK, He XJ. (2013). The PRP6-like splicing factor STA1 is involved in   RNA-directed DNAmethylation by facilitating the   production of Pol V-dependent scaffold RNAs.Nucleic Acids Research. 2013 Oct;41(18):8489-502. (#, equally   contributed)

3.      Han YF#, Dou K#, Ma ZY, Zhang SW, Huang HW, Li   L, Cai T, Chen S, Zhu JK, He XJ. (2014). SUVR2 is involved in transcriptional gene silencing   by associating with SNF2-related chromatin-remodeling proteins in   Arabidopsis.Cell Research. 2014   Dec;24(12):1445-65. (#, equally contributed)

4.      Moon S, Madeline C,   Lin Y, Wang L, Dou K, Zhang ZZ.   (2018). A robust transposon-endogenizing response from germline stem cells. Developmental   Cell. 2018 Dec 3;47(5):660-671.e3

5.      Wang CH, Guo X, Dou K, Chen H, Xi R. (2015). Ttk69   acts as a master repressor of enteroendocrine cell specification in   Drosophila intestinal stem cell lineages. Development. 2015 Oct 1;142(19):3321-31.

6.      Zhang CJ, Zhou JX, Liu   J, Ma ZY, Zhang SW, Dou K, Huang   HW, Cai T, Liu R, Zhu JK, He XJ. (2013). The splicing machinery promotes   RNA-directed DNA methylation and transcriptional silencing in Arabidopsis. EMBO   Journal. 2013 Apr 17; 32(8):1128-40.

7.      Li P, Li J, Li M, Dou K, Zhang MJ, Suo F, Du LL.   (2012). Multiple end joining mechanisms repair a chromosomal DNA break in   fission yeast. DNA Repair (Amst).   2012 Feb 1;11(2):120-30