Kun Dou Assistant Professor PI
Dr. Dou obtained her bachelor’s degree in biology from Hunan University in 2009. She gained her Ph.D in Beijing Normal University / National Institute of Biological Sciences, Beijing (NIBS) in 2014, where she studied epigenetic regulation. She worked for one year in NIBS as a postdoc researcher after her Ph.D training and started to usefruit fly as a model organism. She worked as a postdoctoral researcher in Carnegie Institution for Science, department of embryology (located in Johns Hopkins university) from 2015 to 2019 to study transposon biology and epigenetic regulation in fruit fly (Mentor, Dr. Zhao Zhang and Dr. Allan Spradling). She joined School of Life Science and Technology in ShanghaiTech University in Jan. 2020 as an assistant professor (Tenure-track) and PI, focusing on epigenetic regulation and transposon biology.
Transposons, also known as “jumping genes”, are the most abundant residents in almost all eukaryote genomes. Activation of transposons can lead to genome instability and may cause cancer. It was found that more than 75 human diseases can be caused by transposon integration. For example, retrotransposon LINE1 mobilizing into the genomic locus of APC or FVIII led to colon cancer or hemophilia, respectively. Therefore, it is essential to study how transposon invade host genome.
Dr. Dou’s group is using fruit fly as a major model organism to study the following mechanisms: 1) Transposon suppression by the host; 2) Transposon propagation in the host. We will exploit the advantages of fruit fly, including rich genetic resources, short life cycle, to facilitate our study and to uncover new mechanisms. We are also expecting to extend our knowledge in fruit fly to mammalian systems to better understand transposon regulation in mammals.
1. Lu Wang#, Kun Dou#, Sungjin Moon, Frederick J. Tan, ZZ Zhao Zhang. (2018). Hijacking oogenesis enables massive propagation of LINE and retroviral transposons. Cell. 2018. Aug 23;174(5):1082-1094.e12. (Equally contributed, voluntarily to be the latter one)
2. Dou K#, Huang CF#, Ma ZY, Zhang CJ, Zhou JX, Huang HW, Cai T, Tang K, Zhu JK, He XJ. (2013). The PRP6-like splicing factor STA1 is involved in RNA-directed DNAmethylation by facilitating the production of Pol V-dependent scaffold RNAs.Nucleic Acids Research. 2013 Oct;41(18):8489-502. (#, equally contributed)
3. Han YF#, Dou K#, Ma ZY, Zhang SW, Huang HW, Li L, Cai T, Chen S, Zhu JK, He XJ. (2014). SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.Cell Research. 2014 Dec;24(12):1445-65. (#, equally contributed)
4. Moon S, Madeline C, Lin Y, Wang L, Dou K, Zhang ZZ. (2018). A robust transposon-endogenizing response from germline stem cells. Developmental Cell. 2018 Dec 3;47(5):660-671.e3
5. Wang CH, Guo X, Dou K, Chen H, Xi R. (2015). Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages. Development. 2015 Oct 1;142(19):3321-31.
6. Zhang CJ, Zhou JX, Liu J, Ma ZY, Zhang SW, Dou K, Huang HW, Cai T, Liu R, Zhu JK, He XJ. (2013). The splicing machinery promotes RNA-directed DNA methylation and transcriptional silencing in Arabidopsis. EMBO Journal. 2013 Apr 17; 32(8):1128-40.
7. Li P, Li J, Li M, Dou K, Zhang MJ, Suo F, Du LL. (2012). Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast. DNA Repair (Amst). 2012 Feb 1;11(2):120-30