上海科技大学人力资源管理
ShanghaiTech University Human Resources

Quan Wang    Assistant Professor/PI

Institute

School of Life Science     and Technology

Shanghai Institute     for Advanced Immunochemical Institute Studies

Research Area

Microbial bioenergetics;     Mitochondria in immunity; Structure Biology

Contact Info.

wangq@@shanghaitech.edu.cn

 

A person wearing glasses and smiling at the camera  Description automatically generated

 

 

Biography

 

 

Dr. Wang received his   BS degree (2005) and Ph.D. degree (2009) from Nankai University. He was a Research   Assistant Professor in Institute of Biophysics, Chinese Academy of Sciences   in Beijing from 2014-2018, and an Academic Visitor in the Division of   Structural Biology in Nuffield Department of Clinical Medicine and Oxford   Particle Imaging Centre of Oxford University, UK from 2014-2015. He rose to a   Research Associate Professor (2018) and Research Professor (IBP Fellow, Principal   Investigator, 2019) in Institute of Biophysics, Chinese Academy of Sciences.   He joined ShanghaiTech University in 2020 as an Assistant Professor of School   of Life Science and Technology and a Principal Investigator of Shanghai   Institute for Advanced Immunochemical Studies (SIAIS).

 

 

Research Interests

 

 

Dr. Wang committed to   studying the molecular composition, structural characteristics and functional   mechanisms of the energy metabolism system of pathogenic microorganisms such   as Mycobacterium tuberculosis and Helicobacter pylori at   multiple scales by using cryo-electron microscopy and other imaging   techniques. In addition, through interfering biological energy metabolism   system, we carry out drug screening and development to fight the drug-resistant   pathogens and tumors.

 

 

Selected Publications

 

 

Structural Biology

1.    Hongri Gong#; Jun Li#; Ao Xu#; Yanting   Tang; Wenxin Ji; Ruogu Gao; Shuhui Wang; Lu Yu; Changlin Tian; Jingwen Li;   Hsin Yung Yen; Sin Man Lam; Guanghou Shui; Xiuna Yang; Yuna Sun; Xuemei Li;   Minze Jia; Cheng Yang; Biao Jiang; Zhiyong Lou; Carol V Robinson; Luet Lok   Wong; Luke W Guddat; Fei Sun*; Quan Wang*; Zihe Rao*, An electron   transfer path connects subunits of a mycobacterial respiratory supercomplex ,   Science, 2018.10.25, 362(6418): 0~eaat8923 [Representative Publication,   Co-corresponding Author]

2.    Wenxia Liu#; Aijun   Liu; Hailong Gao; Quan Wang; Limin Wang; Eberhard Warkentin; Zihe Rao;   Hartmut Michel*; Guohong Peng*, Structural properties of the peroxiredoxin   AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus, Biochimica et   Biophysica Acta-General Subjects, 2018.12, 1862(12): 2797~2805

3.    Kotecha Abhay#; Wang   Quan; Dong Xianchi; Ilca Serban L; Ondiviela Marina; Zihe Rao; Seago   Julian; Charleston Bryan; Fry Elizabeth E; Abrescia Nicola G A; Springer   Timothy A*; Huiskonen Juha T*; Stuart David I*, Rules of engagement between alpha   v beta 6 integrin and foot-and-mouth disease virus, Nature Communications,   2017.05.23, 8: 0~15408

4.    Dang, Minghao#; Wang,   Xiangxi; Wang, Quan; Wang, Yaxin; Lin, Jianping; Sun, Yuna; Li,   Xuemei; Zhang, Liguo; Lou, Zhiyong; Wang, Junzhi; Rao, Zihe*, Molecular   mechanism of SCARB2-mediated attachment and uncoating of EV71., Protein &   Cell, 2014.9, 5(9): 692~703

5.    Li, Baobin#; Wang,   Quan#;   Pan, Xijiang; Fernandez de Castro, Isabel; Sun, Yuna; Guo, Yu; Tao, Xinwei;   Risco, Cristina; Sui, Sen-Fang; Lou, Zhiyong*, Bunyamwera virus possesses a   distinct nucleocapsid protein to facilitate genome encapsidation.,   Proceedings of the National Academy of Sciences of the United States of   America, 2013.05.28, 110(22): 9048~9053 [Representative Publication,   Co-first Author]

6.    Chen, Qingfeng#; Chen,   Xiangsong#;   Wang, Quan; Zhang, Faben; Lou, Zhiyong*; Zhang, Qifa*; Zhou, Dao-Xiu*,   Structural basis of a histone H3 lysine 4 demethylase required for stem   elongation in rice., PLoS Genetics, 2013, 9(1)

7.    Chen, Qingfeng#; Wang,   Quan; Xiong, Lizhong*; Lou, Zhiyong*, A structural view of the conserved   domain of rice stress-responsive NAC1., Protein Cell, 2011.1, 2(1): 55~63

8.    Wang, Hui#; Morita,   Masahiro; Yang, Xiuna; Suzuki, Toru; Yang, Wen; Wang, Jiao; Ito, Kentaro; Wang,   Quan; Zhao, Cong; Bartlam, Mark*; Yamamoto, Tadashi*; Rao, Zihe, Crystal   structure of the human CNOT6L nuclease domain reveals strict poly(A)   substrate specificity., The EMBO Journal, 2010.8.4, 29 (15): 2566~2576

Drug Discovery

9.    Dong, Jing#; Zhang, Yong;   Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Yang, Cheng; Wang, Quan; Li,   Xuemei*; Deng, Xuming*, Baicalin inhibits the lethality of Shiga-like toxin 2   in mice., Antimicrobial Agents and Chemotherapy, 2015.11, 59(11): 7054~7060

10.Cao, Shujuan#; Yu, Liang;   Mao, Jingyuan; Wang, Quan; Ruan, Jishou*, Uncovering the Molecular   Mechanism of Actions between Pharmaceuticals and Proteins on the AD Network.,   PLos One, 2015, 10(12)

11.Shanshan Qin#; Yiran   Ren#; Xu Fu; Jie Shen; Xin Chen; Quan Wang; Xin Bi; Wenjing Liu; Lixin   Li; Guangxin Liang; Cheng Yang; Wenqing Shui*, Multiple ligand detection and   affinity measurement by ultrafiltration and mass spectrometry analysis   applied to fragment mixture screening, Analytica Chimica Acta, 2015.7.30,   886: 98~106

12.Chen, Xin#; Qin,   Shanshan; Chen, Shuai; Li, Jinlong; Li, Lixin; Wang, Zhongling; Wang,   Quan; Lin, Jianping; Yang, Cheng; Shui, Wenqing*, A ligand-observed mass   spectrometry approach integrated into the fragment-based lead discovery   pipeline., Scientific Reports, 2015, 5: 8361~8361

13.Dong, Jing#; Zhang, Yong;   Chen, Yutao; Niu, Xiaodi; Zhang, Yu; Li, Rui; Yang, Cheng; Wang, Quan;   Li, Xuemei; Deng, Xuming*, Baicalin inhibits the lethality of ricin in mice   by inducing protein oligomerization., Journal of Biological Chemistry,   2015.5.15, 290(20): 12899~12907

14.Dazhi Liu#; Zhen Tian;   Zhihui Yan; Lixin Wu; Yan Ma; Quan Wang; Wei Liu*; Honggang Zhou;   Cheng Yang, Design, synthesis and evaluation of 1,2-benzisothiazol-3-one   derivatives as potent caspase-3 inhibitors, Bioorganic & Medicinal Chemistry,   2013.6.1, 21(11): 2960~2967