上海科技大学人力资源管理
ShanghaiTech University Human Resources

Tian Hua     Assistant Professor, PI

Institute

iHuman Institute

Research Area

Structural Biology

Contact Info.

huatian@@shanghaitech.edu.cn

 

 








 

Biography

 

 

2007.09   – 2011.07: B.S. in Biotechnology, University of Science and Technology   BeijingChina

2011.09   - 2017.07: Ph.D. in Biochemistry and molecular biology, Institute of   Biophysics, Chinese Academy of Science, Beijing, China.

2017.09 – 2020.02:   Research Associate Professor, iHuman Institute, ShanghaiTech University,   Shanghai, China.

2020.03- present: Assistant Professor and PI, iHuman Institute, ShanghaiTech University,   Shanghai, China.

 

 

Research Interests

 

 

My research focuses on   the molecular dissection and mechanistic understanding of taste receptors,   and also the investigation into the neurological related orphan GPCRs from   pharmacology perspective.

 

 

Selected Publications

 

 

1.   Tian Hua# *, Xiaoting Li#, Lijie Wu#, ChristosIliopoulos   Tsoutsouvas, Yuxia Wang, Meng Wu, Ling Shen, Christina A.Johnston, Spyros   P.Nikas, Feng Song, Xiyong Song, Shuguang Yuan, Qianqian Sun, Yiran Wu, Shan   Jiang, Travis W.Grim, Othman Benchama, Edward L.Stahl, Nikolai Zvonok, Suwen   Zhao, Laura M.Bohn, Alexandros Makriyannis,    Zhi-Jie Liu* (2020) Activation and Signaling Mechanism Revealed by   Cannabinoid Receptor-Gi Complex Structures. Cell, 180(4):655-665.

2.   Jingjing Wang#, Tian Hua* and Zhi-Jie Liu*,   Structural features of activated GPCR signaling complexes. Current Opinion   in Structure Biology, 2020, in press.

3.   Jingjing Wang, Meng Wu, Lijie Wu, Yueming   Xu, Fei Li, Yiran Wu, Petre Popov, Lin Wang, Fang Bai, Suwen Zhao, Zhi-Jie   Liu, Tian Hua*. (2020) The structural study of mutation induced inactivation   of human muscarinic receptor M4. IUCrJ; 7(Pt 2): 294–305.

4.   X. Li#, T. Hua#, K. Vemuri, S. J. Ho, Y.   Wu, L. Wu, P. Popov, O. Benchama, N. Zvonok, K. Locke, L. Qu, GW. Han, M.   Iyer, R. Cinar, N. Coffey, J. Wang, M., Wu, V. Katritch, S. Zhao, G. Kunos,   L. Bohn, A. Makriyannis, R Stevens. Liu ZJ* (2019) Crystal Structure of the   Human Cannabinoid Receptor CB2. Cell, 176(3), 459-467.

5.   R., Laprairie, K., Vemuri, E., Stahl, A.,   Korde, J., Ho, T., Grim, T., Hua, Y., Wu, R. C., Stevens, Z-J, Liu, A.,   Makriyannis and L., Bohn* (2019) Probing the CB1 cannabinoid receptor binding   pocket with AM6538, a high-affinity irreversible antagonist, Mole   Pharmacology, Nov;96(5):619-628.

6.   Tian Hua#, Kiran Vemuri, Spyros P. Nikas,   Robert B. Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang,   Jo-Hao Ho, Gye Won Han, Kang Ding, Xuanxuan Li, Haiguang Liu, Michael A.   Hanson, Suwen Zhao, Laura M. Bohn*, Alexandros Makriyannis*, Raymond C.   Stevens* and Zhi-Jie Liu*. (2017) Crystal structures of agonist-bound human   cannabinoid receptor CB1. Nature, 547(7664):468-471.

7.   T. Hua#, K. Vemuri, M. Pu, L. Qu, GW. Han,   Y. Wu, S. Zhao, W. Shui, S. Li, A. Korde, R. Laprairie, E. Stahl, J. Ho, N.   Zvonok, H. Zhou, I. Kurareva, B. Wu, Q. Zhao, M. Hanson, L. Bohn, A.   Makriyannis, R Stevens. ZJ. Liu (2016) Crystal Structure of the Human   Cannabinoid Receptor CB1. Cell, 167(3):750-762. (Selected as Best of   Cell 2017).

8.   Zhao, L.#, T. Hua #, Crowley, C., Ru, H.,   Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L., Huang, W., Liu, L.,   Ye, K., OuYang, S*, Cheng, G*, and Liu, Z. J*, (2014) Structural analysis of   asparaginyl endopeptidase reveals the activation mechanism and a reversible   intermediate maturation stage, Cell Research, 24(3):344-58.

9.   T. Hua#, Wu, D., Ding, W., Wang, J., Neil,   N*., and Liu, Z. J*, (2012) Studies on human 2, 4 dienoyl CoA reductase (DCR)   sheds new light on peroxisomal β-oxidation of unsaturated fatty acids, J   Biol Chem, 287(34):28956-65.