Lu Zhang Assistant Professor PI
2001-2005 B.S. in Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, China
2005-2008 M.S. in Microbiology, College of Life Sciences, Nankai University, China
2008-2016 Research staff, College of Life Sciences, Nankai University (2013-2016 State Key Laboratory of Medicinal Chemical Biology of Ministry of Science and Technology, China)
2016-2019 Ph.D. in Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, China
2020- Assistant professor \PI, Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and School of Life Science and Technology
(i) Structural study of drug target proteins involved in Mycobacterium Tuberculosis cell wall synthesis and structure based new anti-Tuberculosis drug development.
(ii) Structural and functional studies of disease-related membrane-bound glycosyltransferases (GTs).
Dr. Lu Zhang has contributed to determining the three dimensional structures of multi-pass transmembrane proteins and protein complexes related to drug targets of infectious diseases (i.e. Mycobacterium Tuberculosis) by comprehensively using cryo-EM and X-ray crystallography; concentrated on the glycobiological and biochemical strategy of understanding the functions of membrane-bound glycosyltransferases (GTs). I have now opted for developing new anti-tuberculosis drugs based on 3D structures of the drug targets.
1. Lu Zhang†, Yao Zhao†, et al, Quan Wang*, Jun Li*, Gurdyal S. Besra*, Zihe Rao*.Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol. (2020) Science.368, 1211–1219
2. Lu Zhang†,Yao Zhao†,Ruogu Gao†, et al, Quan Wang*, Gurdyal S. Besra*, Zihe Rao*. Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2. (2020) Protein and Cell. 11(7):505–517
3. Bing Zhang†, Jun Li†,*, Xiaolin Yang, Lijie Wu, Jia Zhang, Yang Yang, Yao Zhao, Lu Zhang, et al., Haitao Yang*, Zihe Rao*. Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. (2019) Cell. 176, 636-648.e613.