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| 个人简介 |  |
| 1997-2001， 南京大学， 生物化学系， 本科 2001-2006， 中科院神经科学研究所， 博士 2006-2010， 美国麻省理工学院， 博士后 2011-2017， 清华大学，生命学院，特聘研究员，博导 2017.11-至今, 上科大生命科学与技术学院，副教授、研究员 |
| 主要研究内容 | |
| 实验室关注于研究哺乳动物大脑中的记忆存储、提取的相关编码规律和神经生物学机制。我们独立发展了大规模单神经元解析度的在体成像技术，寻找和追踪小鼠皮层内神经元群体在长期记忆形成于提取过程中的反应活动特征，探索脑对外界多模态环境的编码存储规律；利用多种手段，解析大脑中存储记忆的特异性神经环路以及表观遗传调控对记忆印迹细胞的作用，研究记忆的灵活性与稳定性调节机制；利用脑机接口等工程与医学手段，探索对脑损伤、脑疾病的修复治疗新方法。 |
| 代表性论文 | |
| a) Xinlu Ding, SanXiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, HaiTeng Deng, Yichang Jia, Wei Xie, Hong Xie & Ji-Song Guan# (2017) Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation. Nat Neurosci. May;20(5):690-699 doi:10.1038/nn.4536 b) Zhu Τ, Liang C, Li D, Tian M, Liu S, Gao G and Guan JS#. (2016) Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α. Sci Rep. 6: 26597. c) Guan JS#, Jiang J, Xie H and Liu K-Y. (2016) How does the sparse memory "Engram": Neurons encode the memory of a spatial-temporal event? Front. Neural Circuits 10: 61. (Review) d) Guan JS#, Xie H, Ding XL. (2015) The role of epigenetic regulation in learning and memory. Exp Neuro. 268: 30-36. e) Xie H, Liu Y, Zhu YZ, Ding XL, Yang YH and Guan JS#. (2014) In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A. 111: 2788-2793. f) Guan JS*, Su SC*, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA and Tsai LH. (2011) Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway. PLoS One 6: e25735. g) Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I and Tsai LH. (2012) An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 483: 222-226. h) Guan JS*, Haggarty SJ*, Giacometti E*, Dannenberg JH*, Joseph N, Gao J, Nieland TJF, Zhou Y, Wang XY, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R and Tsai LH. (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459: 55-60. (full research article) i) Guan JS*, Xu ZZ*, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L and Zhang X (2005) Interaction with vesicle luminal protachykinin regulates surface expression of δ-opioid receptors and opioid analgesia. Cell 122: 619-631. |
