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| 个人简介 |  |
| 2007年7月毕业于南京大学，获学士学位； 2013年1月毕业于中国科学院上海生化细胞所，获博士学位； 2013年1月至2013年7月在生化细胞所担任助理研究员； 2013年8月起在奥古斯塔大学佐治亚医学院从事博士后研究； 2018年1月在上海科技大学生命科学与技术学院担任助理教授、研究员。 |
| 主要研究内容 | |
| 突触是神经元之间或者神经元和效应细胞之间传递信号、构成神经环路的结构和功能单位。突触传递和突触可塑性是大脑行使各项功能包括感觉、运动、认知以及学习记忆的基础。我们实验室主要以小鼠为模式生物，神经肌肉接头为突触模型，利用分子生物学、生物化学、细胞生物学、影像学技术以及电生理等实验手段来研究突触形成和维持的分子机制；以及在衰老、重症肌无力和脊髓侧索硬化症中神经肌肉接头功能变化和调控机制。我们的研究可能为这类疾病的诊断和治疗提供新靶点和思路。 |
| 代表性论文 | |
| 1. Lei Li, Wen-Cheng Xiong and Lin Mei (2018). Neuromuscular junction formation, aging and disorders. Annual Review of Physiology., 80: (1). 2. Lei Li*, Yu Cao*, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chengyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong and Lin Mei (2016). Enzymatic activity of the scaffold protein Rapsyn for synapse formation. Neuron, 92: 1007-1019. (*, equal contribution) 3. Xiang-Dong Sun*#, Lei Li*, Fang Liu, Zhi-Hui Huang, Jonathan. C. Bean, Hui-Feng Jiao, Arnab Barik, Seon-Myung Kim, Haitao Wu, Chengyong Shen, Yun Tian, Thiri W. Lin, Ryan Bates, Anupama Sathyamurthy, Yong-Jun Chen, Dong-Min Yin, Lei Xiong, Hui-Ping Lin, Jin-Xia Hu, Bao-Ming Li, Tian-Ming Gao, Wen-Cheng Xiong and Lin Mei# (2016). Lrp4 in astrocytes modulates glutamatergic transmission. Nat. Neurosci., 19: 1010-1018. (*: equal contribution; #, co-correspondence) 4. Arnab Barik*, Lei Li*, Anupama Sathyamurthy, Wen-Cheng Xiong and Lin Mei (2016). Schwann cells in neuromuscular junction formation and maintenance. J. Neurosci., 36: 9770-9781. (*, equal contribution) 5. Lei Li, Dan Wei, Qiong Wang, Jing Pan, Rong Liu, Xu Zhang and Lan Bao (2012). MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683. 6. Haitao Wu*, Arnab Barik*, Yisheng Lu, Chengyong Shen, Andrew Bowman, Lei Li, Anupama Sathyamurthy, Thiri Lin, Wen-Cheng Xiong and Lin Mei (2015). Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation. eLife, 4: e07266. (*, equal contribution) 7. Arnab Barik*, Yisheng Lu*, A. Sathyamurthy, Andrew Bowman, Chengyong Shen, Lei Li, Wen-Cheng Xiong and Lin Mei (2014). LRP4 is critical for neuromuscular junction maintenance. J. Neurosci., 34: 13892-13905. (*, equal contribution) 8. Huifeng Jiao*, Xiang-Dong Sun*, Ryan Bates*, Lei Xiong, Fang Liu, Lei Li, Shunqi Wang, Mingtao Xiong, Bao-Ming Li, Wen-Cheng Xiong and Lin Mei (2017). Tmem108 is required for glutamatergic transmission in dentate gyrus. PNAS, 114: 1177-1182. 9. Wenjing Li, Chen Zhong, Lei Li, Bingfa Sun, Weiyi Wang, Shutong Xu, Tianlong Zhang, Chungang Wang, Lan Bao and Jianping Ding (2012). Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin. Cell Res., 22: 1707-711. 10. Yuan-Yuan Su, Mingyu Ye, Lei Li, Chao Liu, Jing Pan, Wen-Wen Liu, Xing-Yu Jiang, Xu Zhang, Yousheng Shu and Lan Bao (2013). KIF5B promotes the forward transport and axonal function of voltage-gated sodium channel Nav1.8. J Neurosci., 33: 17884-896. |
