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| 个人简介 |  |
| 1999 B.S. Kyoto University. 2004 Ph.D. Kyoto University. 2004-2009 Postdoctoral Fellow Marie Curie Research Institute 2009-2011 JSPS Special Postdoctoral Research Fellow at the University of Cambridge 2011-2018 Group Leader University of Cambridge 2018- Assistant Professor Shanghaitech University |
| 主要研究内容 | |
| The cell cycle is one of the most fundamental processes for living organisms and the molecular machinery regulating the cell cycle is evolutionally conserved from yeast to man. My laboratory combines advanced genetic methods and in vivo imaging of the fruit fly Drosophila melanogaster with proteomics and genomics approaches and detailed molecular analysis, in order to uncover universal mechanisms integrating cell division into developmental and homeostatic processes of multicellular organisms (http://www.kimatalab.com/). We have recently discovered that the master cell cycle regulator APC/C ubiquitin ligase couples cell fate determination to the cell cycle by regulating an extracellular signalling pathway and the centrosome (Meghini et al., 2016 Nature Comms; Martins et al., 2017 Dev Cell). We are working with international collaborators: Renata Basto (Institute Curie, France), Andrea Brand (Gurdon Institute, UK), and Marc de la Roche (University of Cambridge, UK), to further explore such coupling mechanisms and to apply the findings in flies into mammalian systems. |
| 代表性论文 | |
| 1.Martins T, Meghini F, Florio F, and Kimata Y(Corresponding author) (2017). The APC/C coordinates retinal differentiation withthe cell cycle through the Nek2-dependent modulation of Wingless signalling. Developmental Cell, 40(1):67-80
2.Meghini F, Martins T, Tait X, Fujimitsu K, Yamano H,Glover DM, and Kimata Y (Corresponding author) (2016). Targeting of Fzr/CDH1 for timely activation of theAPC/C at the centrosome during mitotic exit. Nature Communications, 7: 12607.
3.Haider S, Lipinszki Z, Przewloka MR, Ladak Y,D'Avino PP, Kimata Y, Lio' P, Glover DM (2015). DAPPER: a data-miningresource for protein-protein interactions. BioDataMin.,8: 30.
4.Kimata Y, KitamuraK, Fenner N, and Yamano H (2011). Mes1 controls the meiosis I to meiosis IItransition by distinctly regulating the anaphase-promoting complex/cyclosomecoactivators Fzr1/Mfr1 and Slp1 in fission yeast. Mol.Biol. Cell, 22(9): 1486–94.
5.Kimata Y, Baxter JE, Fry AM, and Yamano H. (2008). A role for theFizzy/Cdc20 family of proteins in activation of the APC/C distinct fromsubstrate recruitment. Molecular Cell, 32(4): 576–83.
6.Kimata Y, Trickey M, Izawa D, Gannon J, Yamamoto M, and Yamano H(2008). A mutual inhibition between APC/C and its substrate Mes1 required formeiotic progression in fission yeast. Developmental Cell, 14: 446–454.
7.Hayes MJ*, Kimata Y* (*equal contribution), Wattam SL, Lindon C, Mao G,Yamano H and Fry AM (2006). Early mitotic degradation ofNek2A depends on Cdc20-independent interaction with the APC/C. Nature Cell Biology, 8: 607–614. |
