上海科技大学人力资源管理
ShanghaiTech University Human Resources

Katsuhiko Mikoshiba    Professor  PI

Institute

School of Life Science and Technology

Shanghai Institute for Advanced Immunochemical Studies

Research Area

Cell calcium signaling

Contact Info.

mikosiba@@shanghaitech.edu.cn

  

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Biography

  

  

Education

1969          M.D. Keio University School of Medicine

1973          Ph.D. Keio University

Professional Training and Employment

1973-1974Assistant Professor, Dept. of Physiology,  Keio Univ. School of Medicine

1974-1982Lecturer, Dept. of Physiology, Keio Univ.  School of Medicine

1976-1977 Research Associate Pasteur Institute, Paris, France(c/o Prof. Jean-Pierre   Changeux)

1982-1985 Associate Prof., Department of Physiology,  Keio Univ.School of Med.

1985-1992Professor, Institute for Protein Research,  Osaka University

1986-1991 Professor, National Institute for Basic Biology, Okazaki (Adjunct position)

1992-1997 Chief Scientist, Molecular Neurobiology Laboratory, RIKEN, Tsukuba (Adjunct position)

1992-2007 Professor, The Institute of Medical Science,  The University of Tokyo

1998-2009 Team   Leader, Group Director, RIKEN Brain Science Institute (BSI) (Adjunct   position)

2003-2015 Foreign Professor (Adjunct Professor) at  Karolinska Institute (received an honorary doctorate from Karolinska  Institute)

2005-presentMember   of Science Council of Japan

2007-present Professor Emeritus of University of Tokyo

2008-2011Foreign Professor of Seoul National   University (Korea) (World Class University Professor, WCU Prof. program)

2009-2019Senior Team Leader, Lab. for   Developmental Neurobiol., BSI, RIKEN

2019-presentProfessor,   SIAIS (Shanghai Institutefor Advanced Immunochemical Studies), ShanghaiTech   University

  

  

Research Interests

  

  

Role of calcium   signaling in cell function and diseases.

  

  

Selected Publications

  

  

1.  Furuichi T, et al. Primary structure and   functional expression of the inositol 1,4,5-trisphosphate-binding protein   P400. Nature 342(6245):32-8. (1989)

2.  Miyazaki S et al. Block of Ca2+ wave   and Ca2+ oscillation by antibody to the inositol   1,4,5-trisphosphate receptor in fertilized hamster eggs.  Science 257:251-5.   (1992)

3.  Matsumoto M et al.Ataxia and epileptic seizures   in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379(6561):168-71.   (1996)

4.  Kume S et al., Role of inositol   1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos. Science   278(5345):1940-3. (1997)

5.  Takei K et al. Regulation of nerve growth   mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science   282:1705-1708. (1998)

6.  Nagai, T et al. A variant of yellow fluorescent   protein with fast and efficient maturation for cell-biological   applications.  Nat. Biotechnol. 20 87-90 (2002)

7.  Saneyoshi T et al.  The Wnt/calcium pathway   activates NF-AT and promotes ventral cell fate in Xenopus embryos.  Nature   417:295-299. (2002)

8.  Higo T et al. Subtype-specific and ER   lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate   receptor type 1 by ERp44.   Cell 120(1):85-98. (2005)

9.  Futatsugi A et al. IP3 receptor types 2 and 3   mediate exocrine secretion underlying energy metabolism.   Science   309(5744):2232-4. (2005)

10.  Ando H et al. IRBIT suppresses IP3 receptor   activity by competing with IP3 for the common binding site on the IP3   receptor.   Molecular Cell 22(6):795-806. (2006)

11.  Higo T et al. Mechanism of ER   stress-induced brain damage by IP3 receptor. Neuron 68(5):865-78.   (2010)

12.  Horikawa K et al. Spontaneous network   activity visualized by ultrasensitive Ca2+indicators, yellow   Cameleon-Nano. Nature Methods 7:729-732. (2010)

13.  Klar   J et al. InsP3R2 mutations cause  anhidrosis in humans   and hypohidrosis in mice.   J. Clinical Investigation    124(11): 4773-80 (2014)

  

14.Tsuboi D et al. Disrupted-in-schizophrenia 1 regulates   transport of ITPR1 mRNA for synaptic plasticity. Nat   Neurosci. 18(5): 698-707. (2015)

  

14. Hisatsune C et al. ERp44 Exerts redox-dependent   control of blood pressure at the ER. Molecular   Cell. 58(6): 1015-27.   (2015)

15. Monai H et al. Calcium imaging reveals glial   involvement in transcranial direct current stimulation-induced plasticity in   mouse brain. Nature Commundoi:   10.1038/ncomms11100 (2016)

  

16.  Bonneau B et al. IRBIT controls apoptosis by interacting with the Bcl-2   homolog, Bcl2l10, and by promoting ER-mitochondria contact.eLifeDOI10.7554/eLife19896 (2016)

17.   Hamada K, et al. IP3-mediated   gating mechanism of the IP3 receptor revealed by mutagenesis and   X-ray crystallography.Proc Natl Acad Sci U S A.114(18):   4661-4666. (2017)