Katsuhiko Mikoshiba Professor PI
|
|
| Biography |
|
Education 1969 M.D. Keio University School of Medicine 1973 Ph.D. Keio University Professional Training and Employment 1973-1974Assistant Professor, Dept. of Physiology, Keio Univ. School of Medicine 1974-1982Lecturer, Dept. of Physiology, Keio Univ. School of Medicine 1976-1977 Research Associate Pasteur Institute, Paris, France(c/o Prof. Jean-Pierre Changeux) 1982-1985 Associate Prof., Department of Physiology, Keio Univ.School of Med. 1985-1992Professor, Institute for Protein Research, Osaka University 1986-1991 Professor, National Institute for Basic Biology, Okazaki (Adjunct position) 1992-1997 Chief Scientist, Molecular Neurobiology Laboratory, RIKEN, Tsukuba (Adjunct position) 1992-2007 Professor, The Institute of Medical Science, The University of Tokyo 1998-2009 Team Leader, Group Director, RIKEN Brain Science Institute (BSI) (Adjunct position) 2003-2015 Foreign Professor (Adjunct Professor) at Karolinska Institute (received an honorary doctorate from Karolinska Institute) 2005-presentMember of Science Council of Japan 2007-present Professor Emeritus of University of Tokyo 2008-2011Foreign Professor of Seoul National University (Korea) (World Class University Professor, WCU Prof. program) 2009-2019Senior Team Leader, Lab. for Developmental Neurobiol., BSI, RIKEN 2019-presentProfessor, SIAIS (Shanghai Institutefor Advanced Immunochemical Studies), ShanghaiTech University |
| Research Interests |
|
Role of calcium signaling in cell function and diseases. |
| Selected Publications |
|
1. Furuichi T, et al. Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400. Nature 342(6245):32-8. (1989) 2. Miyazaki S et al. Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science 257:251-5. (1992) 3. Matsumoto M et al.Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379(6561):168-71. (1996) 4. Kume S et al., Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos. Science 278(5345):1940-3. (1997) 5. Takei K et al. Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones. Science 282:1705-1708. (1998) 6. Nagai, T et al. A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat. Biotechnol. 20 87-90 (2002) 7. Saneyoshi T et al. The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 417:295-299. (2002) 8. Higo T et al. Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44. Cell 120(1):85-98. (2005) 9. Futatsugi A et al. IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism. Science 309(5744):2232-4. (2005) 10. Ando H et al. IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor. Molecular Cell 22(6):795-806. (2006) 11. Higo T et al. Mechanism of ER stress-induced brain damage by IP3 receptor. Neuron 68(5):865-78. (2010) 12. Horikawa K et al. Spontaneous network activity visualized by ultrasensitive Ca2+indicators, yellow Cameleon-Nano. Nature Methods 7:729-732. (2010) 13. Klar J et al. InsP3R2 mutations cause anhidrosis in humans and hypohidrosis in mice. J. Clinical Investigation 124(11): 4773-80 (2014)
14.Tsuboi D et al. Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. Nat Neurosci. 18(5): 698-707. (2015)
14. Hisatsune C et al. ERp44 Exerts redox-dependent control of blood pressure at the ER. Molecular Cell. 58(6): 1015-27. (2015) 15. Monai H et al. Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nature Commundoi: 10.1038/ncomms11100 (2016)
16. Bonneau B et al. IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.eLifeDOI10.7554/eLife19896 (2016) 17. Hamada K, et al. IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.Proc Natl Acad Sci U S A.114(18): 4661-4666. (2017) |