上海科技大学人力资源管理
ShanghaiTech University Human Resources
王皞鹏    助理教授、研究员
所在学院 生命科学与技术学院
研究方向 T细胞活性的调节，共刺激/抑制信号通路，肿瘤免疫
联系方式 wanghp@@shanghaitech.edu.cn
 
  个人简介  
2003年本科毕业于南京大学理科教学强化部；2009年在美国田纳西大学健康医学中心获博士学位；2009年至2015年在加州大学旧金山分校医学院进行博士后研究；2015年7月加入上海科技大学生命科学与技术学院任助理教授、研究员。
  主要研究内容  
最近,以免疫细胞为靶标的肿瘤免疫疗法取得了重大的突破。免疫学家利用大分子药物来增强病人自身T细胞的抗癌能力，成功地治愈了癌症病人。我们的科研工作聚焦于T细胞活化的调节机制，我们结合蛋白质组学,CRISPR筛选以及小鼠遗传学等方法探索T细胞受体以及共刺激分子CD28 受体家族的下游信号通路。我们的研究将帮助寻找肿瘤免疫的新靶点。
  代表性论文  
  1. Tian R*, Wang H*, Pasculescu A, Shi Y, Gish G, Hunter T, Gingras A, Pawson T, Weiss A. Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T cell co-stimulatory receptor PNAS 2015 12; 1594-1603 (*equal contribution)
  2. Punwani D*, Wang H*, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM. Combined Immunodeficiency due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation.  J Clin. Immunol. 2015 35 135-146(* equal contribution)
  3. Wang H*, Flach H*, Onizawa M, Wei L, McManus MT, Weiss A. Negative regulation of Hif1α expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210. Nature Immunology 2014 15; 393–401 (* equal contribution)
  4. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator. Molecular Cell. 2013 49(2):273-82.
  5. Wang H, Kadlecek T, Au-Yeung B, Sjölin Goodfellow H, Hsu LY, Freedman T, Weiss A. ZAP-70: an essential kinase in T cell signaling. Cold Spring Harb Perspect Biol. 2010 1;2(5).
  6. Wang H, Holst J, Woo S, Guy CS, Bettni M, Wang Y, Aaron S, Naramura M, Mingueneau M, Dragone L, Hayes S, Malissen B, Band H, Vignali DA. Tonic Ubiquitylation controls T cell receptor:CD3 complex expression during T cell development. EMBO J. 2010 7;29(7):1285-98.
  7. Wang H, Matsuzawa A, Brown SA, Zhou J, Guy CS, Tseng PH, Forbes K, Nicholsonll TP, Sheppardll PW, Haecker H, Karin M, Vignali DA. Analysis of non-degradative protein ubiquitylation with a monoclonal antibody specific for K63-linked polyubiqutin. PNAS 2008 105(51):20197-202.
  8. Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nature Immunology 2008 9(12):1364-70.
  9. Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nature Immunology 2008 9(6):658-66.
  10. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 2008 321(5889):663-8.