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| 个人简介 |  |
| 1997－2001年就读于山东大学生命科学院，获微生物学学士学位 2001－2004年就读于山东大学生命科学院，获微生物学硕士学位 2004－2009年就读于清华大学生命科学院，获生物物理学博士学位 2009－2012年在耶鲁大学从事博士后研究 2012－2014年在威斯康星大学麦迪逊分校从事博士后研究 2014－2016年在加州大学伯克利分校从事博士后研究 2016年7月加入上海科技大学，在iHuman研究所任PI（Research Associate Professor），在生命科学与技术学院任助理教授 |
| 主要研究内容 | |
| 本研究组的主要研究方向是利用冷冻电子显微学作为主要技术手段研究蛋白与膜相互作用系统，并结合生物化学，荧光超分辨成像，X-射线晶体学以及分子动态模拟来深刻理解蛋白与膜相互作用的机制；同时，利用胞内系统进一步验证所得到的作用机制。希望通过这些研究来加深理解重要蛋白与膜系统的分子机制，为解决蛋白与膜系统紊乱引起的疾病提供坚实的结构生物学基础。本研究组主要集中在以下几个方向： 1.转运必需内体复合体（ESCRT）剪切膜系统的分子机制 2.G蛋白偶联受体（GPCR）的结构生物学研究 3.嵌合于脂双层的膜蛋白结构冷冻电镜解析方法的开发与应用 同时，如果你对我们的工作感兴趣，真诚地欢迎加盟或合作。 |
| 代表性论文 | |
| 1. Lars-Anders Carlson, Qing-Tao Shen, Mark Remec Pavlin, James H. Hurley (2015) ESCRT filaments as spiral springs. Developmental Cell, 35(4): 397-398 2. Qing-Tao Shen, Xuefeng Ren, Rui Zhang, II-Hyung Lee, James H. Hurley (2015) HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons. Science, 350(6259): aac5137 (Faculty 1000 recommended) 3. Bei Yang, Goran Stjepanovic, Qing-Tao Shen, Andreas Martin, James H. Hurley (2015) The AAA+ ATPase dissembles ESCRT-III by global unfolding and pore translocation. Nature Structural & Molecular Biology, 22(6): 492-498 4. Qing-Tao Shen, Amber L. Schuh, Yuqing Zheng, Marisa S Otegui, Paul Alquist, Qiang Cui, Anjon Audhya (2014) Structural analysis and modeling reveals new mechanisms governing ESCRT-III spiral filament assembly. Journal of Cell Biology (Cover Story), 206(6):763-777 (Highlighted in Journal of Cell Biology 206(5)) (Faculty 1000 recommended) 5. Zi-Chao Yu, Xiu-Lan Chen, Qing-Tao Shen, Dian-Li Zhao, Bai-Lu Tang, Hai-Nan Su, Zhao-Yu Wu, Qi-Long Zhao, Bin-Bin Xie, Xiying Zhang, Yong Wu, Bai-Cheng Zhou, Bo Chen, Yu-Zhong Zhang (2014) Filamentous phages prevalent in Psuedoalteromonas spp. confer properties advantageous to host survival in Arctic sea ice. ISME Journal, 1-11 6. Lei Shi, Kevin Howan, Qing-Tao Shen, Yong Jian Wang, James E Rothman, Frederic Pincet (2013) Preparation and characterization of SNARE-containing nanodiscs and direct study of cargo release through fusion pores. Nature Protocols, 8:935-948 7. Qing-Tao Shen, Peter Hsiue, Charles V. Sindeler, Matthew D. Weltch, Ken G. Campellone, Hong-Wei Wang (2012) Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. Journal of Cell Biology (Cover Story), 199(1): 111-124(In focus by Journal of Cell Biology 199(1)) 8. Lei Shi, Qing-Tao Shen, Alexander Kiel, Jing Wang, Hong-Wei Wang, Thomas J. Melia, James E. Rothman, Frederic Pincet (2012) SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open. Science, 335(6074):1355-1359 9. Xiaoyang Wu, Qing-Tao Shen, Daniel S. Oristian, Catherine P. Lu, Qinsi Zheng, Hong-Wei Wang and Elaine Fuchs (2010) Skin Stem Cells Orchestrate Directional Migration by Regulating Microtubule-ACF7 Connections through GSK3β. Cell, 144(3):341-352 10. Qing-Tao Shen, Xiao-Chen Bai, Lei-Fu Chang, Yi Wu, Hong-Wei Wang, Sen-Fang Sui (2009) Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control. Proc. Natl. Acad. Sci. USA, 106:4858-4863 11. Xiao-Yan Song, Qing-Tao Shen, Shu-Tao Xie, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2006) Broad-spectrum antimicrobial activity and high stability of Trichokonins from Trichoderma koningii SMF2 against plant pathogens. FEMS Microbial Lett., 260(1):119-125 12. Chang-Zhen Liu, Li He, Qing-Tao Shen, Xiang-Hui Li, Sen-Fang Sui (2005) Leucine zipper domain is important for actin binding of p57. Progress in Biochemistry and Biophysics, 32(8):718-725 13. Qing-Tao Shen, Xiu-Lan Chen, Cai-Yun Sun, Yu-Zhong Zhang (2004) Dissecting and exploiting nonribosomal peptide synthetases. Acta Biochim Biophys Sin (Shanghai), 36(4):243-249 |
