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| 个人简介 |  |
| 1997年本科毕业于北京工商大学化学工程系； 2004年在中科院上海生物化学与细胞生物学研究所获得博士学位； 2004-2011年在美国麻省大学医学院进行博士后研究，2011年晋升为研究员。 2018年6月加入上海科技大学生命科学与技术学院任助理教授、研究员。 |
| 主要研究内容 | |
| 基因的开关转换在细胞命运决定，发育和人类疾病中起到关键的作用。本实验室主要从事表观遗传学和染色高级结构的研究。将结合单细胞基因组学，基于CRISPR的DNA和RNA跟踪和编辑技术，以及超高分辨率活细胞显微成像等技术来研究基因的时空调节以及细胞的命运决定。最终我们将设计分子机器来调节或修复基因并探索其在疾病治疗中的应用。目前的主要研究方向：1）基因组的3D结构和动态变化在基因表达和调控中的作用；2）表观遗传修饰对转录调节的分子机制；3）相分离在基因激活和沉默的作用。 |
| 代表性论文 | |
| (# Co-first author, * Corresponding author) 1. Ma H*, Tu LC, Naseri A, Chung YC, Grunwald D, Zhang S, Pederson T. (2018) CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging. Nat. Methods. 15: 928-931.2. Ma H*, Reyes-Gutierrez P, Pederson T. (2018) ACRISPR-Based Selective Gene Inhibition Method Reveals Dynamic Features of aCell Nucleus Nanobody Related to the Disease Myotonic Dystrophy. SmallMethods. 1700400. 3. Chuai G, MaH, Yan J, Chen M, Hong N, Xue D, Zhou C, Zhu C, Chen K, Duan B, Gu F, Qu S,Huang D, Wei J, Liu Q. (2018) DeepCRISPR: Optimized CRISPR Guide RNA Design byDeep Learning. Genome Biol. 19(1): 80. 4. Ma H*, Tu LC, Naseri A, Chung YC, Grunwald D,Zhang S, Pederson T. (2017) CRISPR-Based Imaging Reveals Cell-Cycle-DependentChromosome Dynamics in Living Cells. BioRxiv 195966; doi.org/10.1101/195966 5. Ma H*, TuLC, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T. (2016) MultiplexedLabeling of Genomic Loci with dCas9 and Engineered sgRNAs using CRISPRainbow. Nat.Biotechnol. 34: 528-530. 6. Ma H#, TuLC#, Naseri A, Huisman M, Zhang S, Grunwald D, Pederson T*. (2016) CRISPR-Cas9Nuclear Dynamics and Target Recognition in Living Cells. J. Cell Biol. 214:529-537. (Highlighted in an “InFocus” editorial) 7. Ma H*, Naseri A, Reyes-Gutierrez P, Wolfe SA, Zhang S,Pederson T*. (2015) Multicolor CRISPR Labeling of Chromosomal Loci in HumanCells. Proc. Natl. Acad. Sci. USA 112: 3002-3007. 8. Ma H,McLean JR, Gould KL, McCollum D. (2014) An Efficient Fluorescent Protein-BasedMultifunctional Affinity Purification Approach in Mammalian Cells. MethodsMol. Biol. 1177:175-191. (Invited protocol) 9. Ma H*,Reyes-Gutierrez P, Pederson T*. (2013) Visualization of Repetitive DNASequences in Human Chromosomes with Transcription Activator-Like Effectors. Proc.Natl. Acad. Sci. USA. 110:21048-21053. 10. Ma, H* &Pederson T*. (2013) The Nucleolus Stress Response is Coupled to anATR-Chk1-Mediated G2 Arrest. Mol.Biol. Cell 24: 1334-1342. 11. Ma H,McLean JR, Chao LF, Mana-Capelli S, Paramasivam M, Hagstrom KA, Gould KL,McCollum D. (2012) A Highly Efficient Multifunctional Tandem AffinityPurification Approach Applicable to Diverse Organisms. Mol. Cell. Proteomics 11: 501-511. 12. Ma H &Pederson T. (2008) Nucleophosmin is a Binding Partner of Nucleostemin in HumanOsteosarcoma Cells. Mol. Biol. Cell 19: 2870-2875. 13. Ma H* &Pederson T. (2008) Nucleostemin: a Multiplex Regulator of Cell-CycleProgression. Trends Cell Biol. 18: 575-579. 14. Ma H &Pederson T. (2007) Depletion of the Nucleolar Protein Nucleostemin Causes G1 Cell Cycle Arrest via the p53 Pathway. Mol. Biol. Cell 18: 2630-2635. 15. Ma HH, Yang L, Yang XY, Xu ZP, Li BL. (2003) Bacterial Expression,Purification, and in vitro N-Myristoylation of Fusion Hepatitis B Virus preS1with the Native-Type N-terminus. Protein Expr. Purif. 27: 49-54.
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